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CEPHALEXIN MONOHYDRATE

Product Name
CEPHALEXIN MONOHYDRATE
CAS No.
23325-78-2
Chemical Name
CEPHALEXIN MONOHYDRATE
Synonyms
KEFLEX;CEFALEXIN HYDRATE;CEPHALEXIN HYDRATE;Cephalexin (400 mg);cefalexin monohydrat;Cefalexin(coMpacted);CEFALEXIN MONOHYDRATE;CEPHALEXIN MONOHYDRATE;Cefalexine Monohydrate;Cephalexin Monohydrate USP
CBNumber
CB4153386
Molecular Formula
C16H19N3O5S
Formula Weight
365.4
MOL File
23325-78-2.mol
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CEPHALEXIN MONOHYDRATE Property

refractive index 
154 ° (C=0.5, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
NH4OH 1 M: 50 mg/mL, clear, yellow
form 
solid
Water Solubility 
13.5g/L(25 ºC)
Merck 
14,1974
BRN 
965503
InChIKey
AVGYWQBCYZHHPN-KJTIIWGRSA-N
CAS DataBase Reference
23325-78-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-45-24/25
WGK Germany 
3
RTECS 
XI0350000
HS Code 
29419052
Toxicity
LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4895
Product name
Cephalexin hydrate
Purity
first-generation cephalosporin antibiotic
Packaging
5 g
Price
$132
Updated
2021/03/22
Sigma-Aldrich
Product number
C0675000
Product name
Cephalexin monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
c0675000
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
C0675000
Product name
Cephalexin monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
C4895
Product name
Cephalexin hydrate
Purity
first-generation cephalosporin antibiotic
Packaging
10 g
Price
$234
Updated
2021/03/22
Sigma-Aldrich
Product number
1099008
Product name
Cephalexin
Packaging
400mg
Price
$366
Updated
2020/08/18
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CEPHALEXIN MONOHYDRATE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Ceporex,Glaxo,UK,1970

Uses

Cephalosporin antibacterial.

Uses

A semisynthetic cephalorsporin antibiotic.

Uses

Semi-synthetic cephalosporin antibiotic.

Definition

ChEBI: The hydrate of cephalexin.

Manufacturing Process

To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine (0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7- aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride salt was added, followed by triethylamine (12.1 ml) and dimethylformamide (140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2 hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To the resultant solution, hydrochloric acid (54 ml) was added followed by zinc (21.8 g) in portions over a period of 5 minutes, the temperature being maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and the solution stirred at 15°C to 20°C for 7 hours.
The pH was adjusted to 3.3 with triethylamine and semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200 ml) and the cephalexin recovered, yield 75%.

brand name

Keflex (Panixine (Ranbaxy).

Therapeutic Function

Antibiotic

CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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CEPHALEXIN MONOHYDRATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999- ;0411-62910999-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3753
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
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View Lastest Price from CEPHALEXIN MONOHYDRATE manufacturers

Dideu Industries Group Limited
Product
CEPHALEXIN MONOHYDRATE USP/EP/BP 23325-78-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-29
Shaanxi Dideu Medichem Co. Ltd
Product
Cephalexin monohydrate 23325-78-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23
career henan chemical co
Product
CEPHALEXIN MONOHYDRATE 23325-78-2
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-25

23325-78-2, CEPHALEXIN MONOHYDRATERelated Search:


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  • CEPHALEXIN MONOHYDRATE BP USP GRADE
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  • Biochemistry