7-Amino-3-methyl-3-cephem-4-carboxylic acid

Product Name: 7-Amino-3-methyl-3-cephem-4-carboxylic acid
CAS No.: 22252-43-3
Chemical Name: 7-Amino-3-methyl-3-cephem-4-carboxylic acid
Synonyms: 7-ADCA;7-ACT;ADCA;PENKB;SCA23;5-Phenyl-2;7-ACA-7-ADCA;4-dienoic acid;5-Phenylpenta-2;D-7-ACA Impurity 1
CBNumber: CB7497894
Molecular Formula: C8H10N2O3S
Formula Weight: 214.24
MOL File: 22252-43-3.mol

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7-Amino-3-methyl-3-cephem-4-carboxylic acid Property

Melting point:: 234°C (dec.)
Boiling point:: 517.6±50.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 20℃
refractive index: 104 ° (C=1, 1mol/L HCl)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.04±0.50(Predicted)
form: powder
color: White to Orange to Green
Water Solubility: Soluble in water (partly), 1M ammonium hydroxide (50 mg/ml), and DMSO (Sparingly).
BRN: 5273616
Stability:: Stable. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m1/s1
InChIKey: NVIAYEIXYQCDAN-CLZZGJSISA-N
SMILES: N12[C@@]([H])([C@H](N)C1=O)SCC(C)=C2C(O)=O
LogP: -3.8--2.8 at 20℃ and pH3.6-7
CAS DataBase Reference: 22252-43-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43-36/37/38-20/21/22
Safety Statements: 36-26
WGK Germany: 3
HS Code: 2941901010
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3004
Product name: Cefadroxil Related Compound B
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $353
Updated: 2025/07/31

Sigma-Aldrich

Product number: A8398
Product name: 7-Aminodesacetoxycephalosporanic acid
Packaging: 1g
Price: $319
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP011
Product name: 7-Aminodesacetoxycephalosporanic acid
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 20 mg
Price: $231
Updated: 2025/07/31

Sigma-Aldrich

Product number: A0460000
Product name: 7-Aminodesacetoxycephalosporanic acid
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 30 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1097126
Product name: Cefadroxil Related Compound B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1130
Updated: 2025/07/31

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7-Amino-3-methyl-3-cephem-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A metabolite of Cephalexin (C256800).

Uses

7-Aminodesacetoxycephalosporanic acid is the Cephalexin metabolite. It is a Potent inhibitor of bacterial cell-wall enzyme. It is used in the synthesis of cephalosporins and for bioconversion studies.

Definition

ChEBI: A cephem monocarboxylic acid derivative having a structure based on cephalosporanic acid, deacetoxylated and carrying a 7beta-amino group.

Biological Activity

7-ADCA is produced from penicillin G made by Penicillium chrysogenum involving several polluting chemical steps followed by enzymatic deacylation using penicillin acylase .

Synthesis

The existing preparation method usually employs acylase to cleave 7-phenylacetamidocephalosporanic acid, and then obtains 7-ADCA by acidification, dichloromethane extraction to remove impurities, activated charcoal decolorization and crystallization, etc. However, in this process, after obtaining the cleavage solution, the steps of removing impurities and decoloration are more cumbersome, and after decoloration with activated charcoal, in the subsequent reaction process, some of the substances come into contact with oxygen in the air, and are prone to appear color again, and the effect of removing impurities and decolorization is poor.

7-Amino-3-methyl-3-cephem-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl 7-amino-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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7-Amino-3-methyl-3-cephem-4-carboxylic acid Suppliers

Americas 1 Australia 1 Belgium 1 Brazil 1 Canada 2 China 229 Europe 2 France 1 Germany 4 India 22 Italy 1 Japan 1 Nepal 1 Singapore 1 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 10 United States 45 Global 328

Suizhou Jiake Biological Engineering Co., Ltd.

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View Lastest Price from 7-Amino-3-methyl-3-cephem-4-carboxylic acid manufacturers

Jinan Finer Chemical Co., Ltd

Product: 7-Amino-3-methyl-3-cephem-4-carboxylic acid 22252-43-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 100mt
Release date: 2019-07-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7β-aminodeacetoxycephalosporanic acid 22252-43-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: 7-Amino-3-methyl-3-cephem-4-carboxylic acid 22252-43-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

22252-43-3, 7-Amino-3-methyl-3-cephem-4-carboxylic acidRelated Search:

POLYURETHANE 4-Aminobenzoic acid Bensulfuron methyl Kresoxim-methyl Methylparaben Benzocaine Urethane Methyl acrylate 6-Aminocaproic acid 3-Hydroxy-4-Methyl-2(5H)-thiophenone (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- 7-Amino-3-chloro cephalosporanic acid D-2-Phenylglycine Thiophanate-methyl Glycine Methyl Parathion-methyl Anthranilic acid

Cefazedone Impurity 13

Cefadroxil Impurity 8（Cefadroxil EP Impurity B）

Cephalexin EP Impurity B (Cephalexin Impurity B, 7-ADCA)

Cefadroxil EP Impurity B

Cefadroxil Related Compound B (25 mg) ((6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid)

Cefalexin EP Impurity B

Cefadroxil EP Impurity B (Cephalexin Impurity B, 7-ADCA)

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-aMino-3-Methyl-8-oxo-, (6R,7R)-

Cefazedone Related Impurity 13

7beta-aminodeacetoxycephalosporanic acid

Cefadroxil impurity

Cefalexin impurity B

Cefalexin Impurity 2(EP Impurity B)

7-ACA-7-ADCA

ADCA

(7R)-3-Methyl-7-aminocepham-3-ene-4-carboxylic acid

(7R)-7-Amino-3-methylcepham-3-ene-4-carboxylic acid

3-Methyl-7β-aminocepham-3-ene-4-carboxylic acid

7-ACT

7-amino-3-methyl-3-cephem-4-carboxylic

7-Aminodezacetoxycephalosporanic acid

7-Amino deacetoxy cefalosporanic acid

7-Amino-3-desacetoxy cephalosporanic acid

6R,7R)-7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

7-Amino-3-deacetoxycephalosporanic Acid

Deacetoxycephalosporanic Acid

7-AMINODESACETOXY- CEPHALOSPORANIC ACID 98.5%

(6R-trans)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-ADCA

7-Amino-3-methyl-3-cephem-4-carboxylic acid

7-Aminodeacetoxycephalosporanic ccid

7-Aminodesacetoxycephalosporanic Aicd

Cefalexine EP IMpurity B

Cephalexin IMpurity B

Cefadroxil Related CoMpound B

7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-4-carboxylic acid

7-aminodesacetoxycephalosporanic acid (Cefadroxil Monohydrate Impurity B)

Cephalexin EP impurity B

7-Aminodesacetoxycephalosporanic Ac

7-Aminodesacetoxycephalosporanic Acid &gt

7-Aminodesacetoxycephalosporanic acid CRS

Cephalexin Impurity B (Cefadroxil Impurity B, 7-ADCA)

Cefalexin Impurity 2（Cefalexin EP Impurity B）

7-Amino-3-methyl-3-cephem-4-carboxylic acidr

7β-aminodeacetoxycephalosporanic acid

Cefalexin EP Impurity B?(7-ADCA/ 7-Aminodesacetoxycephalosporanic acid)

7-Aminodesacetoxycephalosporanic acid (A0460000)

Cephalexin Impurity B (7-ADCA)Q: What is Cephalexin Impurity B (7-ADCA) Q: What is the CAS Number of Cephalexin Impurity B (7-ADCA) Q: What is the storage condition of Cephalexin Impurity B (7-ADCA) Q: What are the applications of Cephalexin Impurity B (7-ADCA)

Cefadroxil Related Compound B ((6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2 (1097126)

4-dienoic acid

4-pentadienoic acid

5-Phenyl-2

5-Phenylpenta-2

7- aminodeacetyloxy captidine acid

7-amino-3-deacetyloxy cephalosporane

Cefadroxil USP Related Compound B

7β-aminodeacetoxycephalosporanicaci

Cefalexin EP Impurity B(Cefadroxil EP Impurity B)