CEPHALEXIN MONOHYDRATE

ChemicalBook > CAS DataBase List > CEPHALEXIN MONOHYDRATE

CEPHALEXIN MONOHYDRATE

Product Name: CEPHALEXIN MONOHYDRATE
CAS No.: 23325-78-2
Chemical Name: CEPHALEXIN MONOHYDRATE
Synonyms: KEFLEX;CEFALEXIN HYDRATE;CEPHALEXIN HYDRATE;Cephalexin (400 mg);cefalexin monohydrat;Cefalexin(coMpacted);Cephalexin (1099008);CEPHALEXIN 1-HYDRATE;CEFALEXIN MONOHYDRATE;CEPHALEXIN MONOHYDRATE
CBNumber: CB4153386
Molecular Formula: C16H19N3O5S
Formula Weight: 365.4
MOL File: 23325-78-2.mol

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CEPHALEXIN MONOHYDRATE Property

Melting point:: >161°C (dec.)
refractive index: 154 ° (C=0.5, H2O)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: NH₄OH 1 M: 50 mg/mL, clear, yellow
form: solid
color: White to Light Beige
Water Solubility: 13.5g/L(25 ºC)
Merck: 14,1974
BRN: 965503
Stability:: Unstable in Solution
InChIKey: AVGYWQBCYZHHPN-KJTIIWGRSA-N
CAS DataBase Reference: 23325-78-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43
Safety Statements: 22-36/37-45-24/25
WGK Germany: 3
RTECS: XI0350000
HS Code: 29419052
Toxicity: LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0675000
Product name: Cephalexin monohydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: c0675000
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1099008
Product name: Cephalexin
Packaging: 400mg
Price: $436
Updated: 2024/03/01

Usbiological

Product number: 257237
Product name: Cephalexin hydrate
Packaging: 100g
Price: $355
Updated: 2021/12/16

AK Scientific

Product number: 3535AH
Product name: Cephalexinmonohydrochloride
Packaging: 25g
Price: $392
Updated: 2021/12/16

Chem-Impex

Product number: 38384
Product name: Cephalexinmonohydrate,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 25G
Price: $292.36
Updated: 2021/12/16

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CEPHALEXIN MONOHYDRATE Chemical Properties,Usage,Production

Description

Cephalexin was first synthesized in 1967 by Glaxo Research Laboratories and first produced on an industrial scale by Eli Lilly & Co. in the same year. It is a deacetoxylated derivative of cephaloglycin that is not metabolized in vivo. When administered orally, it shows a much higher serum concentration and much lower tendency to induce diarrhea than cephaloglycin. Cephalexin has been used widely and is the most popular orally active antibiotic in the world for treatment of respiratory tract, urinary tract, surgical, ear and nose, and other infections caused by Staphylococcus, Streptococcus, Escherichia coli, Klebsiella, Enterobacter, and Proteus.

Chemical Properties

White to Off-White Solid

Originator

Ceporex,Glaxo,UK,1970

Uses

Cephalosporin antibacterial.

Uses

Semi-synthetic cephalosporin antibiotic.

Uses

A semisynthetic cephalorsporin antibiotic.

Definition

ChEBI: The hydrate of cephalexin.

Manufacturing Process

To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine (0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7- aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride salt was added, followed by triethylamine (12.1 ml) and dimethylformamide (140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2 hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To the resultant solution, hydrochloric acid (54 ml) was added followed by zinc (21.8 g) in portions over a period of 5 minutes, the temperature being maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and the solution stirred at 15°C to 20°C for 7 hours.
The pH was adjusted to 3.3 with triethylamine and semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200 ml) and the cephalexin recovered, yield 75%.

brand name

Keflex (Panixine (Ranbaxy).

Therapeutic Function

Antibiotic

CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CEPHALEXIN MONOHYDRATE manufacturers

Apeloa production Co.,Limited

Product: Cephalexin monohydrate 23325-78-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 112000
Release date: 2024-06-03

Hebei Weibang Biotechnology Co., Ltd

Product: CEPHALEXIN MONOHYDRATE 23325-78-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Mojin Biotechnology Co., Ltd

Product: CEPHALEXIN MONOHYDRATE 23325-78-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-11

23325-78-2, CEPHALEXIN MONOHYDRATERelated Search:

D-2-Phenylglycine 7-Amino-3-methyl-3-cephem-4-carboxylic acid L-Cephalexin 2,5-Piperazinedione, 3-(hydroxymethylene)-6-phenyl- Cephalexin Sulfoxide Cephalexin Diketopiperazine [6R-[6α,7β(R*)]]-7-[(AMinophenylacetyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0 Phenylglycylcefalexin [6R-[6α,7β(R*)]]-7-[(AMinophenylacetyl)aMino]-3-Methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid SodiuM Salt (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- 3-Hydroxy-4-Methyl-2(5H)-thiophenone CEPHALEXIN MONOHYDRATE MICRO/COMPACTED CEPHALEXIN MONOHYDRATE CEPHALEXIN-D5, HYDROCHLORIDE HYDRATE Cephalexin monohydrate,compacted Cephalexin monohydrate, powder CEPHALEXIN MONOHYDRATE--N/H (pivaloyloxy)methyl [6R-[6alpha,7beta(R*)]]-7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monohydrochloride

CEPHALEXIN HYDRATE

CEPHALEXIN MONOHYDRATE

CEFALEXIN HYDRATE

5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-

cefalexin monohydrat

CEPHALEXIN MONOHYDRATE BP USP GRADE

CEFALEXIN MONOHYDRATE

KEFLEX

Cephalexin monhydrochloride

Cephalexin (400 mg)

Cephalexin (400 mg)J0D296996ug/mg(an)

Cefalexin(coMpacted)

Cefalexine Monohydrate

[6R-[6alpha,7beta(R*)]]-7-(2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cephalexin Monohydrate USP

(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-me thyl-8-oxo-5-thia-1-azabi

Cephalexin Monohydrate (Discontinued See C256800)

CEPHALEXIN MONOHYDRATE USP/EP/BP

Cephalexin MonohydrateQ: What is Cephalexin Monohydrate Q: What is the CAS Number of Cephalexin Monohydrate Q: What is the storage condition of Cephalexin Monohydrate

Cephalexin (1099008)

CEPHALEXIN 1-HYDRATE

cephalexin monohydrfate

Cephalexin hydrate in 0.1 M HCl

23325-78-2

C16H17N3O4SH2O

KEFLEX

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