CONGLOBATIN

Product Name: CONGLOBATIN
CAS No.: 72263-05-9
Chemical Name: CONGLOBATIN
Synonyms: NGLOBATIN;FW-04-806;CONGLOBATIN;Conglobactin;Conglobatin, >=99%;Conglobatin (FW-04-806);(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-;(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
CBNumber: CB3460272
Molecular Formula: C28H38N2O6
Formula Weight: 498.61
MOL File: 72263-05-9.mol

More

Less

CONGLOBATIN Property

Density: 1.060±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form: White to off-white solid.
color: White to off-white

More

Less

Safety

WGK Germany: 3
HS Code: 29419000

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00017
Product name: Conglobatin
Purity: ≥90% (LC/MS-ELSD)
Packaging: 1mg
Price: $443
Updated: 2025/07/31

Cayman Chemical

Product number: 21766
Product name: Conglobatin
Purity: ≥98%
Packaging: 500μg
Price: $203
Updated: 2024/03/01

Cayman Chemical

Product number: 21766
Product name: Conglobatin
Purity: ≥98%
Packaging: 2.5mg
Price: $914
Updated: 2024/03/01

Usbiological

Product number: C7852-52
Product name: Conglobatin
Packaging: 500ug
Price: $482
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546129
Product name: Conglobatin
Purity: >98%
Packaging: 200μg
Price: $198.9
Updated: 2021/12/16

More

Less

CONGLOBATIN Chemical Properties,Usage,Production

Uses

Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.

Uses

Conglobatin is a macrolide dilactone from Streptomyces. It exhibits anticancer and immunosuppressant properties.

in vivo

Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner^[2].
Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity^[3]

Animal Model:	BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft^[2]
Dosage:	50, 100, 200 mg/kg
Administration:	Oral gavage every 3 days for 24 days
Result:	Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively. Was well tolerated.

IC 50

HSP90

CONGLOBATIN Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CONGLOBATIN Suppliers

China 34 Germany 1 United Kingdom 2 United States 8 Global 45

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1502
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

72263-05-9, CONGLOBATINRelated Search:

ISOBUTYL TIGLATE CONGLOBATIN

(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

FW-04-806

CONGLOBATIN

Conglobatin, >=99%

1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-

Conglobactin

(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

NGLOBATIN

Conglobatin (FW-04-806)

72263-05-9

Antibiotic