CONGLOBATIN

Product Name: CONGLOBATIN
CAS No.: 72263-05-9
Chemical Name: CONGLOBATIN
Synonyms: NGLOBATIN;FW-04-806;CONGLOBATIN;Conglobactin;Conglobatin, >=99%;Conglobatin (FW-04-806);(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-;(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
CBNumber: CB3460272
Molecular Formula: C28H38N2O6
Formula Weight: 498.61
MOL File: 72263-05-9.mol

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CONGLOBATIN Property

Density: 1.060±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form: White to off-white solid.
color: White to off-white

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Safety

WGK Germany: 3
HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00017
Product name: Conglobatin
Purity: ≥90% (LC/MS-ELSD)
Packaging: 1mg
Price: $443
Updated: 2025/07/31

Cayman Chemical

Product number: 21766
Product name: Conglobatin
Purity: ≥98%
Packaging: 500μg
Price: $203
Updated: 2024/03/01

Cayman Chemical

Product number: 21766
Product name: Conglobatin
Purity: ≥98%
Packaging: 2.5mg
Price: $914
Updated: 2024/03/01

Usbiological

Product number: C7852-52
Product name: Conglobatin
Packaging: 500ug
Price: $482
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546129
Product name: Conglobatin
Purity: >98%
Packaging: 1mg
Price: $554.2
Updated: 2021/12/16

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CONGLOBATIN Chemical Properties,Usage,Production

Uses

Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.

Uses

Conglobatin is a macrolide dilactone from Streptomyces. It exhibits anticancer and immunosuppressant properties.

in vivo

Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner^[2].
Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity^[3]

Animal Model:	BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft^[2]
Dosage:	50, 100, 200 mg/kg
Administration:	Oral gavage every 3 days for 24 days
Result:	Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively. Was well tolerated.

IC 50

HSP90

CONGLOBATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CONGLOBATIN Suppliers

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72263-05-9, CONGLOBATINRelated Search:

ISOBUTYL TIGLATE CONGLOBATIN

(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

FW-04-806

CONGLOBATIN

Conglobatin, >=99%

1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-

Conglobactin

(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

NGLOBATIN

Conglobatin (FW-04-806)

72263-05-9

Antibiotic