1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER

Uses

Product Name: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
CAS No.: 680596-79-6
Chemical Name: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
Synonyms: 4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane;1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL;1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER;1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester;1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER;(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER;1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901;1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester;8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspi...;8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
CBNumber: CB3460797
Molecular Formula: C14H23BO4
Formula Weight: 266.14
MOL File: 680596-79-6.mol

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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Property

Melting point:: 60-62°C
Boiling point:: 313.9±52.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
color: White to Orange to Green
InChI: InChI=1S/C14H23BO4/c1-12(2)13(3,4)19-15(18-12)11-5-7-14(8-6-11)16-9-10-17-14/h5H,6-10H2,1-4H3
InChIKey: JCHWHOHZZYWUMP-UHFFFAOYSA-N
SMILES: O1C2(CCC(B3OC(C)(C)C(C)(C)O3)=CC2)OCC1

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 741671
Product name: 1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $550
Updated: 2023/06/20

Sigma-Aldrich

Product number: 741671
Product name: 1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester
Purity: 97%
Packaging: 500mg
Price: $390
Updated: 2023/01/07

TCI Chemical

Product number: T3566
Product name: 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
Packaging: 250MG
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: T3566
Product name: 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
Packaging: 1G
Price: $116
Updated: 2025/07/31

Usbiological

Product number: 411359
Product name: 1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester
Packaging: 100mg
Price: $305
Updated: 2021/12/16

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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Uses

1,4-Dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester is used as a pharmaceutical intermediate.

Synthesis

73183-34-3

170011-47-9

680596-79-6

1,4-Dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate (500 mg, 1.73 mmol) and pinacol bis(boronic acid) ester (530 mg, 2.08 mmol) were used as the raw materials, and 1,4-dioxane (8 mL) was used as the solvent under nitrogen protection, and potassium acetate (260 mg, 2.64 mmol) and Pd(dppf) Cl2 (130 mg, 0.17 mmol). The reaction mixture was stirred at 110 °C for 10 hours. After completion of the reaction, the insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure and purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v=2/1) to afford 540 mg of the yellow oily product 1,4-dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester in 99% yield.

References

[1] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0431; 0432; 0433
[2] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 20
[3] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 102
[4] Patent: WO2017/192811, 2017, A1. Location in patent: Paragraph 00173
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5377 - 5380

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Suppliers

China 176 Europe 1 Germany 1 India 2 Japan 2 United Kingdom 3 United States 16 Global 201

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View Lastest Price from 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

680596-79-6, 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTERRelated Search:

Tetrahydrofuran E-HEXEN-1-YLBORONIC ACID BUTYLDIISOPROPOXYBORANE Isopropenylboronic acid pinacol ester 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Cyclohexene-1-boronic acid pinacol ester HEXYLBORONIC ACID PINACOL ESTER 1-CYCLOHEXENYLBORONIC ACID n-Butylboronic acid TRANS-1-HEXENYLBORONIC ACID PINACOL ESTER E-2-(1-PENTENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 1-Hexaneboronic acid 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID 2-BUTYL-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER

4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1,4-dioxaspiro[4.5]dec-7-en-8-ylboronate

2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene

2-(1,4-Dioxaspiro[4.5]dec-8-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER

8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene

(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER

1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester

1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL

8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspi...

1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester

2-{1,4-dioxaspiro[4.5]dec-7-en-8-yl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D24870]

680596-79-6

C14H23BO4

Organic boronic acid

blocks

BoronicAcids