Description References
ChemicalBook > CAS DataBase List > Polysorbate 20

Polysorbate 20

Description References
Product Name
Polysorbate 20
CAS No.
9005-64-5
Chemical Name
Polysorbate 20
Synonyms
TWEEN 20;SORBITAN MONOLAURATE;capmul;PEG-80 SORBITAN LAURATE;Polisorbate 20- PS 20;POLYSORBATE 21;POLYOXYETHYLENE SORBITAN MONOLAUREATE;POLYETHYLENE GLYCOL SORBITAN MONOLAURATE;Tween 20 (Trademark of ICI America, Inc.);POLYOXYETHYLENE (20) SORBITAN MONOLAURATE
CBNumber
CB3462544
Molecular Formula
C26H50O10
Formula Weight
522.6692
MOL File
9005-64-5.mol
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Polysorbate 20 Property

Melting point:
98.9 °C (decomp)
Boiling point:
100 °C
Density 
1.11 g/mL at 20 °C
vapor pressure 
<1.4 hPa (20 °C)
refractive index 
n20/D 1.468(lit.)
FEMA 
2915 | POLYSORBATE 20
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
100 g/L
form 
viscous liquid
Specific Gravity
1.090～1.130 (20/20℃)
color 
Amber
PH Range
7
Odor
mild alcohol odor
PH
6-8 (50g/l, H2O, 20℃)
biological source
synthetic
Odor Type
alcoholic
Water Solubility 
100 g/L
Hydrophilic-Lipophilic Balance (HLB)
16.7
Stability:
Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry System
Polysorbate 20 (9005-64-5)
Absorption
= 0.025 at 254nm at 0.05% (w/v)
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Safety

Hazard Codes 
Xi
Risk Statements 
22-36/37/38-37/38-41
Safety Statements 
24/25-36/37/39-36-26
WGK Germany 
1
RTECS 
TR7400000
F 
10-23
TSCA 
Yes
HS Code 
34021300
Hazardous Substances Data
9005-64-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 38900 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7949
Product name
TWEEN® 20
Purity
BioXtra, viscous liquid
Packaging
2.5L
Price
$293
Updated
2024/03/01
Sigma-Aldrich
Product number
P1379
Product name
TWEEN® 20
Purity
viscous liquid
Packaging
1KIT
Price
$137
Updated
2024/03/01
Sigma-Aldrich
Product number
9480-OP
Product name
TWEEN® 20
Packaging
1L
Price
$98.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22184
Product name
TWEEN® 20
Purity
for synthesis
Packaging
50mL
Price
$32.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22184
Product name
TWEEN® 20
Purity
for synthesis
Packaging
500mL
Price
$49.2
Updated
2024/03/01
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Polysorbate 20 Chemical Properties,Usage,Production

Description

Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.

References

https://en.wikipedia.org/wiki/Polysorbate_20
http://www.organic-creations.com/thickeners-stabilizers/599-polysorbate-20

Chemical Properties

Polysorbate 20 is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides. It has a faint, characteristic odor and a warm, somewhat bitter taste.

Chemical Properties

Yellow liquid

Uses

Used for solubilizing membrane proteins during isolation and purification.Polysorbate 20 is used as a wetting agent in flavored mouth drops. It acts as a washing agent in Western blots and ELISAs and prevents antibody binding. It is a solubilizing agent of membrane proteins. In pharmaceutical chemistry, it is used as an excipient to stabilize emulsions and suspensions. Further, it is used as a dispersing agent, stabilizer, lubricator and also used in creams, salves, ointments, protective creams, balms, pomades, lipsticks, mascaras and glosses.

Uses

polysorbate 20 is a solubilizer, emulsifier, viscosity modifier, and stabilizer of essential oils in water.

Preparation

polysorbate 20 is prepared by condensing the partial esters of sorbitol and its anhydrides with ethylene oxide to effect an oxyethylene copolymerization at the free hydroxyl groups.

Definition

ChEBI: Polysorbate 20 (Tween 20) is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group. It is a surfactant and emulsifier used in cleaners and personal care products.

brand name

Tween 20 (ICI Americas).

General Description

Polysorbate 20 is a hydrophilic nonionic surfactant generally used as emulsifiers, dispersing agent and solubilizer.

Health effects

Polysorbate 20 was a skin irritant in dermatitis patients but was reported not to induce irritant responses when applied to the intact skin of health volunteers. It produced, at worst, minimal irritation in the eyes of rabbits. Only a small number of cases of skin sensitization have been reported in humans, although a moderate to strong sensitizing potential was seen in guinea-pigs treated by intradermal injection.

Flammability and Explosibility

Non flammable

Biological Activity

Tween(R) 20, functioning as a detergent, potentially operates by binding to the hydrophobic components of water-insoluble substances, thereby making them hydrophilic.

Safety Profile

Moderately toxic by intravenous route. Mddly toxic by ingestion. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Polysorbate 20 Preparation Products And Raw materials

Raw materials

ETHYLENE OXIDE Sodium ethoxide

Preparation Products

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Polysorbate 20 Suppliers

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View Lastest Price from Polysorbate 20 manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Polysorbate 20 9005-64-5
Price
US $55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Polysorbate 20 9005-64-5
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-26
HebeiShuoshengImportandExportco.,Ltd
Product
Tween 20 9005-64-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-07

9005-64-5, Polysorbate 20Related Search:

Cremophor EL Polyoxyethylene lauryl ether Span 80 POLYETHYLENE GLYCOL MONOOLEYL ETHER Polyethylene Glycol Monocetyl Ether Span 20 EMULSIFIER Tween 60 Polyethylene Glycol alkyl phenyl polyoxyethylene ether polysorbate 40 Triton X-100 Sorbitol Span 60 Tween 80 HEPTAETHYLENE GLYCOL MONODODECYL ETHER TWEEN 65 Tween 85

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