BW 245C
- Product Name
- BW 245C
- CAS No.
- 72814-32-5
- Chemical Name
- BW 245C
- Synonyms
- BW 245C;3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid;3-(3-CYCLOHEXYL-3-HYDROXYPROPYL)-2,5-DIOXO-(R*,S*)-(+/-)-4-IMIDAZOLINEHEPTANOIC ACID;(4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)-;4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel-;4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel-
- CBNumber
- CB3463374
- Molecular Formula
- C19H32N2O5
- Formula Weight
- 368.47
- MOL File
- 72814-32-5.mol
BW 245C Property
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 30 mg/mL, soluble
- form
- solid
- pka
- 4.77±0.10(Predicted)
- color
- off-white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 12050
- Product name
- BW 245C
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 12050
- Product name
- BW 245C
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 12050
- Product name
- BW 245C
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- B820013
- Product name
- BW245C
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- C3027
- Product name
- BW245C
- Packaging
- 1mg
- Price
- $77
- Updated
- 2021/12/16
BW 245C Chemical Properties,Usage,Production
Uses
BW 245C is a DP agonist, affecting the signaling pathway on primary cultured rat hippocampal neuron injuries.
Definition
ChEBI: (3R,4S)-BW 245C is a 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid that is the (3R,4S)-enantiomer of BW 245C. It is an enantiomer of a (3S,4R)-BW 245C.
Biological Activity
bw 245c is a kind of prostaglandin analogue with stable chemical properties which functions as a potent inhibitor of platelet aggregation. bw 245c could selectively active the dp1 receptor, and inhibit [3h]-pgd2 binding to isolated human platelet membranes, with the ki value of 0.9 nm [1].
in vitro
bw 245c could inhibit the aggregation of human and rat platelets induced by adp in a dose dependent manner, with the ic50 values of 8.7 nm and 9.9 nm, respectively [1]. besides, in hek293 cells stably expressing the hdp receptor, bw 245c could significantly increase camp production, with the ec50 value of 0.7 nm [2].
in vivo
in spontaneously hypertensive rats, intravenous bolus injection with bw 245c at the dose of 250 μg/kg could reduce the systolic and diastolic blood pressure by 23% and 34%, respectively [1].
target
dp1 receptor
IC 50
2.5 nm
References
[1] town h c, casalsstenzel j, schillinger e, et al. pharmacological and cardiovascular properties of a hydantoin derivative, bw 245 c, with high affinity and selectivity for pgd2 receptors[j]. prostaglandins, 1983, 25(1): 13-28.
[2] boie y, sawyer n, slipetz d, et al. molecular cloning and characterization of the human prostanoid dp receptor[j]. journal of biological chemistry, 1995, 270(32): 18910-18916.
[3] orchard m a, ritter j m, shepherd g l, et al. cardiovascular and platelet effects in man of bw 245c, a stable mimic of epoprostenol (pgi2)[j]. british journal of clinical pharmacology, 1983, 15(5): 509-511.
BW 245C Preparation Products And Raw materials
Raw materials
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