R-121,919

Product Name: R-121,919
CAS No.: 195055-03-9
Chemical Name: R-121,919
Synonyms: NBI 30775;R-121,919;R121919,R-121919;R121919 (NBI-30775);-4-methylpyridin-3-yl);R121919, 10 mM in DMSO;NBI30775;R 121919;R-121919;-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine;3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7;3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-am
CBNumber: CB3464821
Molecular Formula: C22H32N6
Formula Weight: 380.53
MOL File: 195055-03-9.mol

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R-121,919 Property

Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6.2 mg/mL (16.29 mM)
form: Solid
pka: 6.33±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3114
Product name: R121919
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3114
Product name: R121919
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $481
Updated: 2025/07/31

TRC

Product number: D461680
Product name: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Packaging: 10mg
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-6231
Product name: R121919
Purity: 99.84%
Packaging: 50mg
Price: $1440
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009338
Product name: R-121919
Purity: 95.00%
Packaging: 25MG
Price: $546
Updated: 2021/12/16

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R-121,919 Chemical Properties,Usage,Production

Uses

3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine, is a potent and Orally active Corticotropin-Releasing factor 1 receptor antagonists, which is hown to reduce negative emotional symptoms of acute and protracted alcohol withdrawal, and thus used for the treatment of alcoholism.

Biological Activity

R121919 (NBI 30775) is a brain-penetrant, orally available high-affinity corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) antagonist (Ki = 3.5 nM against sauvagine for binding hCRFR1-expressing HEK293 cells; IC50 = 20 nM/CRF-stimulated ACTH release from r at anterior pituitary cells & IC50 = 80 nM/CRF-stimulated cAMP production in hCRFR1-expressing HEK293 cells) without affinity toward CRFR2. In addition to its antistress efficacy in various r at anxiety models (0.63-20 mg/kg p.o.), R121919 also demonstrates therapeutic efficacy and long-term safety in Alzheimerμs disease (AD) mice (20 mg/kg/day s.c.) in vivo.

in vivo

R121919 (NBI30775) dose dependently decreases adrenocorticopin hormone and Corticosterone (HY-B1618) responses to restraint stress in rats. Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10 mg/kg R121919 are 9 and 25%, respectively^[1].
R121919 reduces levels of anxiety in mice with a steep dose-response curve^[2].

IC 50

CRFR1: 2-5 nM (Ki)

R-121,919 Preparation Products And Raw materials

Raw materials

Preparation Products

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R-121,919 Suppliers

China 42 United States 6 Global 48

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195055-03-9, R-121,919Related Search:

2,6-Dimethylaniline N,N-Dimethylaniline 2-Picoline 4-Pyridin-3-yl-2H-pyrazol-3-ylamine R-121,919

NBI30775;R 121919;R-121919

R-121,919

3-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)-2,5-DIMETHYL-N,N-DIPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE

NBI 30775

3-[6-(diMethylaMino)-4-Methyl-3-pyridinyl]-2,5-diMethyl-N,N-dipropyl-pyrazolo[2,3-a]pyriMidine-7-aMine

3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-am

3-[6-(DiMethylaMino)-4-Methyl-3-pyridinyl]-2,5-diMethyl-N,N-dipropylpyrazolo[1,5-a]pyriMidin-7-aMine

-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

-4-methylpyridin-3-yl)

3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7

Pyrazolo[1,5-a]pyrimidin-7-amine, 3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropyl-

R121919 (NBI-30775)

R121919 (NBI-30775) 3-[6-(Dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

R121919,R-121919

R121919, 10 mM in DMSO

195055-03-9