TP0463518

Product Name: TP0463518
CAS No.: 1558021-37-6
Chemical Name: TP0463518
Synonyms: BGE-117;TP0463518;TP0463518, 10 mM in DMSO;HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-;2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
CBNumber: CB34656567
Molecular Formula: C20H18ClN3O6
Formula Weight: 431.83
MOL File: 1558021-37-6.mol

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TP0463518 Property

Boiling point:: 775.8±60.0 °C(Predicted)
Density: 1.512±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM)
form: A solid
pka: 3.63±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0043483
Product name: TP0463518
Purity: 98.02%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0043483
Product name: TP0463518
Purity: 98.02%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573277
Product name: TP0463518
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573277
Product name: TP0463518
Purity: >98%
Packaging: 250mg
Price: $1654.1
Updated: 2021/12/16

ChemScene

Product number: CS-0043483
Product name: TP0463518
Purity: 98.02%
Packaging: 50mg
Price: $2250
Updated: 2021/12/16

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TP0463518 Chemical Properties,Usage,Production

Uses

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

References

[1] Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144. DOI:10.1016/j.ejphar.2018.08.044

TP0463518 Preparation Products And Raw materials

Raw materials

Preparation Products

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TP0463518 Suppliers

China 42 United States 4 Global 46

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Shanghai Anyinuo Biomedical Technology Co., Ltd.

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InvivoChem

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Career Henan Chemica Co

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Shanghai Dongyang Biotechnology Co., Ltd.

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1558021-37-6, TP0463518Related Search:

TP0463518

Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-

BGE-117

HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors

2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid

TP0463518, 10 mM in DMSO

1558021-37-6

1558021-37-0