DDD85646

Product Name: DDD85646
CAS No.: 1215010-55-1
Chemical Name: DDD85646
Synonyms: DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;DDD85646, 10 mM in DMSO;2,6-Dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
CBNumber: CB34666388
Molecular Formula: C21H24Cl2N6O2S
Formula Weight: 495.43
MOL File: 1215010-55-1.mol

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DDD85646 Property

Melting point:: >215°C (dec.)
Boiling point:: 684.3±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
pka: 7.04±0.50(Predicted)
form: Solid
color: Off-White to Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13839
Product name: DDD85646
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 13839
Product name: DDD85646
Purity: ≥98%
Packaging: 5mg
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 13839
Product name: DDD85646
Purity: ≥98%
Packaging: 10mg
Price: $672
Updated: 2024/03/01

TRC

Product number: D195323
Product name: DDD85646
Packaging: 2.5mg
Price: $265
Updated: 2021/12/16

Usbiological

Product number: 445831
Product name: DDD85646
Packaging: 1mg
Price: $410
Updated: 2021/12/16

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DDD85646 Chemical Properties,Usage,Production

Description

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent K_i value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC₅₀ = 6.9 μM).

Uses

DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).

in vivo

DDD85646 (10, 50 mg/kg; Oral administration; 1) has moderate bioavailability (about 20%) in female NMRI mouse models, and the free drug level is higher than EC₉₉ (EC₉₉ is about 6 nM), which can effectively inhibit the proliferation of T. b. brucei^[3].
DDD85646 (0-50 mg/kg; Oral administration; Twice a day; 4 days) kills Trypanosoma brucei by acting on TbNMT in T. b. brucei acute mouse model of HAT^[3].
DDD85646 (50 mg/kg; Oral administration; Twice a day) shows significant antitrypanosomic activity in female NMRI mice models^[3].

Animal Model:	T. b. brucei acute mouse model of HAT^[3]
Dosage:	0-50 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Cured all animals in the T. b. brucei acute mouse model of HAT at a minimal oral dose of 12.5 mg/kg (b.i.d. for 4 days) Prevented 99% of T. b. brucei proliferation Parasite numbers dropped below detectable levels within 12 hours

IC 50

Trypanosoma

References

[1] JULIE A. FREARSON. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness[J]. Nature, 2010, 464 7289: 728-732. DOI: 10.1038/nature08893

DDD85646 Preparation Products And Raw materials

Raw materials

Preparation Products

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DDD85646 Suppliers

China 42 United States 3 Global 45

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Shanghai Dongyang Biotechnology Co., Ltd.

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Email: chemsharker@126.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Country: China
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ShangHai ChuanQian Chemcial Technique Centre

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1215010-55-1, DDD85646Related Search:

DDD85646

DDD 85646 (DDD85646)

Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-

DDD85646 Hydrochloride

African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite

2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide

DDD85646, 10 mM in DMSO

2,6-Dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

1215010-55-1

C21H24Cl2N6O2S