TTK21

Product Name: TTK21
CAS No.: 709676-56-2
Chemical Name: TTK21
Synonyms: TTK2;TTK21;TTK21, 10 mM in DMSO;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
CBNumber: CB34666838
Molecular Formula: C17H15ClF3NO2
Formula Weight: 357.75
MOL File: 709676-56-2.mol

More

Less

TTK21 Property

Boiling point:: 369.8±42.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
form: A crystalline solid
pka: 12.22±0.70(Predicted)
color: White to off-white
InChI: InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
InChIKey: AQJBXYBDNZHZRE-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 10mg
Price: $301
Updated: 2024/03/01

TRC

Product number: C428905
Product name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Packaging: 1mg
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: 7228DT
Product name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Packaging: 50mg
Price: $451
Updated: 2021/12/16

More

Less

TTK21 Chemical Properties,Usage,Production

Description

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

Uses

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

in vivo

CSP-TTK21 (20 mg/kg; i.p.; single dose) can extend the memory duration^[1].
CSP-TTK21 (20 mg/kg; p.o; single dose) enhances long-term potentiation comparably to intraperitoneal injection, suggesting effective memory enhancement in Wild-type mice^[3].
CSP-TTK21 (10 mg/kg; p.o; weekly) promotes motor recovery after spinal cord injury in rats, and enhances the expression of regeneration-associated genes in the prefrontal cortex and cerebellum following spinal cord injury^[3].

Animal Model:	B57BL/6J male ^[1]
Dosage:	CSP-TTK21; 20 mg/kg; single dose
Administration:	i.p.
Result:	Increased histone acetylation significantly in the hippocampus and frontal cortex. CSP-TTK21 crossed the blood-brain barrier and was primarily detected in the brain, liver, and spleen. It promoted differentiation of newly generated neurons in the dentate gyrus. Mice with CSP-TTK21 displayed a persistent memory of the platform location in a Morris water maze task for a longer period compared to controls, demonstrating enhanced long-term memory.

Animal Model:	Wild-type mice ^[3]
Dosage:	CSP-TTK21; 20 mg/kg; single dose
Administration:	p.o.
Result:	The administered compound crossed the blood-brain barrier, induced histone acetylation specifically H4K12ac and H3K14ac marks in the hippocampus, and did not alter basal synaptic transmission. It was found to enhance long-term potentiation comparably to intraperitoneal injection, suggesting effective memory enhancement through oral delivery.

Animal Model:	rats with spinal cord injury^[3]
Dosage:	CSP-TTK21; 10 mg/kg; weekly
Administration:	p.o.
Result:	Rats with CSP-TTK21 showed significant improvement in locomotion and rearing activity compared to controls. Histone acetylation was notably increased in the spinal cord, suggesting enhanced gene expression linked to regeneration and functional recovery. Enhanced histone acetylation levels (H4K12ac, H3K27ac, H3K9ac) were observed in the prefrontal cortex and cerebellum of rats with CSP-TTK21, indicating active epigenetic modifications that support neuronal regeneration and functional recovery.

IC 50

CBP/p300

References

[1] SNEHAJYOTI CHATTERJEE. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.[J]. Journal of Neuroscience, 2013: 10698-10712. DOI: 10.1523/jneurosci.5772-12.2013

TTK21 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TTK21 Suppliers

China 59 United States 4 Global 63

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

709676-56-2, TTK21Related Search:

TTP 22 TTNPB (Arotinoid Acid) Belizatinib

TTK21

Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-

TTK21(CBP-p300 activator TTK21)

TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300

TTK2

TTK21, 10 mM in DMSO

709676-56-2