TTK21

Product Name: TTK21
CAS No.: 709676-56-2
Chemical Name: TTK21
Synonyms: TTK2;TTK21;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
CBNumber: CB34666838
Molecular Formula: C17H15ClF3NO2
Formula Weight: 357.75
MOL File: 709676-56-2.mol

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TTK21 Property

Boiling point:: 369.8±42.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
form: A crystalline solid
pka: 12.22±0.70(Predicted)
InChI: InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
InChIKey: AQJBXYBDNZHZRE-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 21959
Product name: TTK21
Purity: ≥98%
Packaging: 10mg
Price: $301
Updated: 2024/03/01

TRC

Product number: C428905
Product name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Packaging: 1mg
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: 7228DT
Product name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Packaging: 50mg
Price: $451
Updated: 2021/12/16

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TTK21 Chemical Properties,Usage,Production

Description

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

Uses

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

TTK21 Preparation Products And Raw materials

Raw materials

Preparation Products

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TTK21 Suppliers

China 42 United States 3 Global 45

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Tianjin Kailiqi Biotechnology Co., Ltd.

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Email: klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Shanghai Hongye Biotechnology Co. Ltd

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Career Henan Chemica Co

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DC Chemicals

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709676-56-2, TTK21Related Search:

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TTK21

Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-

TTK21(CBP-p300 activator TTK21)

TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300

TTK2

709676-56-2