APX-115 freebase
- Product Name
- APX-115 freebase
- CAS No.
- 1270084-92-8
- Chemical Name
- APX-115 freebase
- Synonyms
- Apx-115 free;APX-115 freebase;Ewha-18278 free base;Isuzinaxib(APX-115 free base);APX-115 free base, 10 mM in DMSO;Isuzinaxib (APX-115 free base) ，S0777;3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol;1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-;plasma,APX 115 free base,NOX,Inhibitor,injury,Nox1,kidney,Ewha18278,APX115,albumin,Ewha 18278,APX115 free base,insulin,Ewha-18278,Nox3,resistance,APX 115,APX-115,NADPH Oxidase,inhibit,creatinine,Nox2
- CBNumber
- CB34667547
- Molecular Formula
- C17H17N3O
- Formula Weight
- 279.34
- MOL File
- 1270084-92-8.mol
APX-115 freebase Property
- Boiling point:
- 493.3±45.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml - form
- Solid
- pka
- 7?+-.0.50(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0087247
- Product name
- APX-115(freebase)
- Purity
- 99.47%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0087247
- Product name
- APX-115(freebase)
- Purity
- 99.47%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0087247
- Product name
- APX-115(freebase)
- Purity
- 99.47%
- Packaging
- 25mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0087247
- Product name
- APX-115(freebase)
- Purity
- 99.47%
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0087247
- Product name
- APX-115(freebase)
- Purity
- 99.47%
- Packaging
- 100mg
- Price
- $1350
- Updated
- 2021/12/16
APX-115 freebase Chemical Properties,Usage,Production
Uses
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
in vivo
APX-115 free base (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[2].
APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels[2].
| Animal Model: | Six-week-old male diabetic db/db mice (C57BLKS/J-leprdb/leprdb)[2] |
| Dosage: | 60?mg/kg |
| Administration: | Oral gavage; per day; for 12 weeks |
| Result: | Significantly improved insulin resistance in diabetic mice. |
IC 50
NOX1; NOX2; NOX4
References
[1] Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. DOI:10.18632/oncotarget.18540
[2] Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. DOI:10.1038/labinvest.2017.2
[3] J. JOO. A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep22389
APX-115 freebase Preparation Products And Raw materials
Raw materials
Preparation Products
APX-115 freebase Suppliers
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