5-Amino-2-chlorobenzoic acid
- Product Name
- 5-Amino-2-chlorobenzoic acid
- CAS No.
- 89-54-3
- Chemical Name
- 5-Amino-2-chlorobenzoic acid
- Synonyms
- 2,5-CABA;3-CARBOXY-4-CHLOROANILINE;5-amino-2-chloro-benzoicaci;5-AMINO-2-CHLOROBENZOIC ACID;3-AMINO-6-CHLOROBENZOIC ACID;2-CHLORO-5-AMINO BENZOIC ACID;5-helium-2-chlorobenzoic acid;Benzoic acid, 5-amino-2-chloro-;5-Amino-2-chlorobenzoic acid,97%;5-Amino-2-chlorobenzoic Acid >
- CBNumber
- CB3466951
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 89-54-3.mol
5-Amino-2-chlorobenzoic acid Property
- Melting point:
- 184-188 °C (lit.)
- Boiling point:
- 250°C (rough estimate)
- Density
- 1.5
- refractive index
- 1.5570 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 479mg/l
- pka
- 1.99±0.25(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- BRN
- 2090422
- InChI
- InChI=1S/C7H6ClNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- GVCFFVPEOLCYNN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(N)=CC=C1Cl
- CAS DataBase Reference
- 89-54-3(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 5-amino-2-chloro- (89-54-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 532495
- Product name
- 5-Amino-2-chlorobenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $44.23
- Updated
- 2025/07/31
- Product number
- A1913
- Product name
- 5-Amino-2-chlorobenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $197
- Updated
- 2025/07/31
- Product number
- A1913
- Product name
- 5-Amino-2-chlorobenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 250g
- Price
- $1361
- Updated
- 2025/07/31
- Product number
- A604095
- Product name
- 5-Amino-2-chlorobenzoic Acid
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 057675
- Product name
- 5-Amino-2-chlorobenzoic acid
- Purity
- 95%
- Packaging
- 100g
- Price
- $46
- Updated
- 2021/12/16
5-Amino-2-chlorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
5-Amino-2-chlorobenzoic Acid is a reagent in the preparation of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
2516-96-3
89-54-3
General procedure for the synthesis of 5-amino-2-chlorobenzoic acid from 2-chloro-5-nitrobenzoic acid: 75 g of 2-chloro-5-nitrobenzoic acid, 59 g of iron powder, 800 mL of ethanol, 150 mL of water, and 115 g of ammonium chloride were added to a reaction flask equipped with a stirrer. The mixture was heated to 78-80°C and the reaction was refluxed for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate=1:3) during the reaction. Upon completion of the reaction, the reaction mixture was filtered while hot and the solids were washed with 150 mL of hot ethanol. The filtrate was dried at 60°C to obtain the crude product. Subsequently, the crude product was dissolved in 400 mL of ethyl acetate and heated to reflux pulping for 2 hours. The mixture was cooled to 0~5°C in a salt bath and then naturally reduced to room temperature and crystallized for more than 30 minutes. The crystals were separated by centrifugation and washed with 50 mL of ethyl acetate. Finally, it was dried under reduced pressure at 50°C to give 60.7 g of yellow solid 5-amino-2-chlorobenzoic acid with 99.1% purity and 95.1% yield.
References
[1] Arzneimittel-Forschung/Drug Research, 1982, vol. 32, # 3, p. 183 - 186
[2] Chemical and Pharmaceutical Bulletin, 1988, vol. 36, # 9, p. 3462 - 3467
[3] Patent: CN106748721, 2017, A. Location in patent: Paragraph 0029; 0030
[4] Angewandte Chemie - International Edition, 1999, vol. 38, # 18, p. 2777 - 2779
[5] Justus Liebigs Annalen der Chemie, 1868, vol. 147, p. 258
5-Amino-2-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2-chlorobenzoic acid Suppliers
- Tel
- --
- Fax
- --
- Country
- Belgium
- ProdList
- 6293
- Advantage
- 73
View Lastest Price from 5-Amino-2-chlorobenzoic acid manufacturers
- Product
- 5-Amino-2-chlorobenzoic acid 89-54-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-11
- Product
- 5-Amino-2-chlorobenzoic acid 89-54-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-24
- Product
- 5-Amino-2-chlorobenzoic acid 89-54-3
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20