ChemicalBook > CAS DataBase List > 6-PHENYL-3(2H)-PYRIDAZINONE

6-PHENYL-3(2H)-PYRIDAZINONE

Product Name
6-PHENYL-3(2H)-PYRIDAZINONE
CAS No.
2166-31-6
Chemical Name
6-PHENYL-3(2H)-PYRIDAZINONE
Synonyms
IFLAB-BB F0921-7014;3-Phenyl-6-pyridazinone;6-Phenyl-2H-pyridazin-3-one;6-phenylpyridazin-3(2H)-one;3-phenyl-1H-pyridazin-6-one;6-PHENYL-3(2H)-PYRIDAZINONE;3-Hydroxy-6-phenylpyridazine;3(2H)-Pyridazinone, 6-phenyl-;6-Phenyl-3(2H)-pyridazinone>6-Phenyl-3(2H)-pyridazinone
CBNumber
CB3468980
Molecular Formula
C10H8N2O
Formula Weight
172.18
MOL File
2166-31-6.mol
More
Less

6-PHENYL-3(2H)-PYRIDAZINONE Property

Melting point:
201-204 °C(lit.)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
11.05±0.40(Predicted)
color 
White to Light yellow
λmax
249nm(HCl aq.)(lit.)
InChI
InChI=1S/C10H8N2O/c13-10-7-6-9(11-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)
InChIKey
IJUIPRDMWWBTTQ-UHFFFAOYSA-N
SMILES
C1(=O)NN=C(C2=CC=CC=C2)C=C1
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
510602
Product name
6-Phenyl-3(2H)-pyridazinone
Purity
98%
Packaging
5g
Price
$243
Updated
2023/01/07
TCI Chemical
Product number
P2060
Product name
6-Phenyl-3(2H)-pyridazinone
Purity
>98.0%(GC)
Packaging
1g
Price
$128
Updated
2025/07/31
TCI Chemical
Product number
P2060
Product name
6-Phenyl-3(2H)-pyridazinone
Purity
>98.0%(GC)
Packaging
5g
Price
$432
Updated
2024/03/01
TRC
Product number
P336778
Product name
6-Phenylpyridazin-3(2H)-one
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
065271
Product name
6-Phenylpyridazin-3(2H)-one
Packaging
25g
Price
$408
Updated
2021/12/16
More
Less

6-PHENYL-3(2H)-PYRIDAZINONE Chemical Properties,Usage,Production

Uses

6-Phenylpyridazin-3(2H)-one is a reagent in the preparation of cyclase activator Runcaciguat, a compound used in the treatment of kidney disease and non-proliferative diabetic retinopathy.

General Description

6-Phenyl-3(2H)-pyridazinone is a pyridazinone derivative that can be prepared from 4,5- dihydro-6-phenyl-3(2H)-pyridazinone. It is reported to be a weak positive inotropic agent. 6-Phenyl-3(2H)-pyridazinone forms the core of compounds that show a potential antiplatelet activity.

Synthesis

98-86-2

298-12-4

2166-31-6

The reaction of 19.6 g (162.95 mmol) acetophenone and 5 g (54.32 mmol) oxaloacetic acid monohydrate was stirred at 100 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to 40 °C, followed by the addition of 20 mL of water and 4 mL of ammonia. The mixture was extracted twice with 50 mL of dichloromethane. To the resulting aqueous phase, 2.64 mL (53.32 mmol) of hydrazine monohydrate was added, and the reaction was continued with stirring of the mixture at 100 °C for 2 hours. At the end of the reaction, the reaction solution was cooled to room temperature. The precipitated crystals were collected by filtration, washed with water and dried in a vacuum oven at 50 °C overnight. Finally, 4.3 g (24.97 mmol, 15% yield) of 6-phenyl-3-pyridazinone was obtained as colorless crystals.LC-MS (Method 7): Rt = 1.39 min; m/z = 173 (M + H)+. 1H-NMR (400 MHz, DMSO-d6, δ/ppm): 13.2 (s, 1H), 8.04 (d, 1H), 7.86 (d, 2H), 7.53-7.41 (m, 3H), 7.00 (d, 1H).

References

[1] Patent: US2011/34450, 2011, A1. Location in patent: Page/Page column 103
[2] Patent: US2012/28971, 2012, A1. Location in patent: Page/Page column 24-25
[3] Synthesis, 1993, # 3, p. 334 - 342
[4] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2553 - 2560
[5] Letters in Drug Design and Discovery, 2013, vol. 10, # 6, p. 507 - 514

6-PHENYL-3(2H)-PYRIDAZINONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-PHENYL-3(2H)-PYRIDAZINONE Suppliers

Austria 1 Canada 1 China 101 France 1 India 5 Japan 1 Switzerland 3 United Kingdom 4 United States 12 Global 129
Tianyuan Natural Product Co.,Ltd.
Tel
028-85012281 13808177790
Fax
86-28-85121102
Email
xianlihong8888@163.com
Country
China
ProdList
45
Advantage
62
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
918
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
More
Less

View Lastest Price from 6-PHENYL-3(2H)-PYRIDAZINONE manufacturers

Shanghai Rlavie Technology Co ltd
Product
3-phenyl-1H-pyridazin-6-one 2166-31-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%minHPLC
Supply Ability
100kgs/month
Release date
2021-11-15
Dideu Industries Group Limited
Product
6-PHENYL-3(2H)-PYRIDAZINONE 2166-31-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02
Career Henan Chemical Co
Product
6-PHENYL-3(2H)-PYRIDAZINONE 2166-31-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

2166-31-6, 6-PHENYL-3(2H)-PYRIDAZINONERelated Search:

DICLOMEZINE Isamfazone ZARDAVERINE 4,5-DIHYDRO-6-[4-(1H-IMIDAZOL-1-YL)PHENYL]-3(2H)-PYRIDAZINONE Chloridazon 5-amino-4-bromo-2-phenyl-3(2h)-pyridazinon 4,5-DICHLORO-2-PHENYL-3(2H)-PYRIDAZINONE 4-Chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone,4-chloro-5-(methylamino)-2-(3-(trifluoromethyl)phenyl)-3(2h)-pyridazinon 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE 6-HYDROXY-2-PHENYL-3(2H)-PYRIDAZINONE 4,5-DIBROMO-2-PHENYL-3(2H)-PYRIDAZINONE 2,3,4,5-TETRAHYDRO-6-PHENYL-3(2H)-PYRIDAZINONE,4,5-DIHYDRO-6-PHENYL-3(2H)-PYRIDAZINONE 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER 6-PHENYL-3(2H)-PYRIDAZINONE 6-METHYL-2-PHENYL-3-(2H)-PYRIDAZINONE 4-AMINO-6-PHENYL-3(2H)-PYRIDAZINONE

  • 6-Phenyl-2,3-dihydropyridazine-3-one
  • 3-phenyl-1H-pyridazin-6-one
  • 3-Phenyl-6-pyridazinone
  • 2,3-Dihydro-3-oxo-6-phenylpyridazine, (6-Oxo-1,6-dihydropyridazin-3-yl)benzene
  • 6-Phenyl-3(2<i>H</i>)-pyridazinone
  • 6-PHENYL-3(2H)-PYRIDAZINONE
  • 8-(2-hydroxypropan-2-yl)-2-furo[2,3-h][1]benzopyranone
  • JR-8471, 6-Phenyl-3-(2H)-pyridazinone, 97%
  • IFLAB-BB F0921-7014
  • 6-phenylpyridazin-3(2H)-one
  • 6-Phenyl-2H-pyridazin-3-one
  • 6-Phenyl-3(2H)-pyridazinone&gt
  • 3(2H)-Pyridazinone, 6-phenyl-
  • 3-Hydroxy-6-phenylpyridazine
  • 6-PHENYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH
  • 2166-31-6
  • Pyridazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridazines