5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE
- Product Name
- 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE
- CAS No.
- 90766-97-5
- Chemical Name
- 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE
- Synonyms
- 5-Bromo-6-phenylpyridazin-3(2H)-one;5-Bromo-6-phenyl-2H-pyridazin-3-one;5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE;3(2H)-Pyridazinone, 5-bromo-6-phenyl-;5-bromo-6-phenyl-2,3-dihydropyridazin-3-one
- CBNumber
- CB5743511
- Molecular Formula
- C10H7BrN2O
- Formula Weight
- 251.08
- MOL File
- 90766-97-5.mol
5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE Property
- Melting point:
- 234-237
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- color
- Light brown
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B997183
- Product name
- 5-Bromo-6-phenyl-3(2H)-pyridazinone
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- HCH0024566
- Product name
- 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1115.96
- Updated
- 2021/12/16
- Product number
- 4H56-9-V3
- Product name
- 5-Bromo-6-phenyl-2H-pyridazin-3-one
- Packaging
- 10g
- Price
- $368
- Updated
- 2021/12/16
- Product number
- 043042
- Product name
- 5-Bromo-6-phenyl-3(2H)-pyridazinone
- Purity
- >95%
- Packaging
- 5g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- HCH0024566
- Product name
- 5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $722.8
- Updated
- 2021/12/16
5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE Chemical Properties,Usage,Production
Synthesis
72857-86-4
90766-97-5
The general procedure for the synthesis of 5-bromo-6-phenylpyridazin-3(2H)-one from 3,4-dibromo-5-phenylfuran-2(5H)-one was as follows: to a solution of 3,4-dibromo-5-phenylfuran-2(5H)-one (600 mg, 1.887 mmol) in ethanol (5 mL) at 0 °C, hydrazine hydrate (0.102 mL, 2.076 mmol). The reaction mixture was stirred at room temperature for 10 min, followed by heating to reflux and kept for 2 h. The reaction was carried out on a cooled surface with the addition of hydrazine hydrate (1.076 mmol). Upon completion of the reaction, the mixture was cooled to room temperature, at which time a precipitate was generated. The precipitate was collected by filtration and washed with cold ethanol to give the final 5-bromo-6-phenylpyridazin-3(2H)-one (458 mg, 99% yield) as a light orange solid.LCMS analysis showed m/z = 251 [M + H]+ .
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 5, p. 1030 - 1035
[2] Journal of Heterocyclic Chemistry, 1998, vol. 35, # 6, p. 1421 - 1428
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 9, p. 2873 - 2882
[4] Patent: WO2010/77275, 2010, A1. Location in patent: Page/Page column 95
5-BROMO-6-PHENYL-3(2H)-PYRIDAZINONE Preparation Products And Raw materials
Raw materials
Preparation Products
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