ChemicalBook > CAS DataBase List > IP7E
IP7E
- Product Name
- IP7E
- CAS No.
- 500164-74-9
- Chemical Name
- IP7E
- Synonyms
- IP7E;IP7e, 10 mM in DMSO;Nurr1 Activator, IP7e;isoxazolo-pyridinone 7e;inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one;Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one
- CBNumber
- CB34732562
- Molecular Formula
- C23H22N2O4
- Formula Weight
- 390.43
- MOL File
- 500164-74-9.mol
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IP7E Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM; Ethanol: 20 mM, warmed
- form
- A solid
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29726
- Product name
- IP7e
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29726
- Product name
- IP7e
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
Tocris
- Product number
- 5699
- Product name
- IP7e
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $184
- Updated
- 2021/12/16
Tocris
- Product number
- 5699
- Product name
- IP7e
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $774
- Updated
- 2021/12/16
Usbiological
- Product number
- 452435
- Product name
- IP7e
- Packaging
- 1mg
- Price
- $368
- Updated
- 2021/12/16
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IP7E Chemical Properties,Usage,Production
Uses
IP7e is an activator of Nurr1 signaling pathway.
Biological Activity
Cell permeable: yes', 'Primary Target
Nurr1/NR4A2
in vivo
IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2].
| Animal Model: | Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)[2]. |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i. |
| Result: | Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration. |
IC 50
Nurr1/NR4A2
storage
Store at +4°C
IP7E Preparation Products And Raw materials
Raw materials
Preparation Products
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IP7E Suppliers
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9119
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 025-85560043 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 11438
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 021-69985186 13611928337
- 3427709316@qq.com
- Country
- China
- ProdList
- 7982
- Advantage
- 58