IP7E

Product Name: IP7E
CAS No.: 500164-74-9
Chemical Name: IP7E
Synonyms: IP7E;IP7e, 10 mM in DMSO;Nurr1 Activator, IP7e;isoxazolo-pyridinone 7e;inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one;Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one
CBNumber: CB34732562
Molecular Formula: C23H22N2O4
Formula Weight: 390.43
MOL File: 500164-74-9.mol

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IP7E Property

storage temp.: Store at -20°C
solubility: DMSO: 100 mM; Ethanol: 20 mM, warmed
form: A solid
color: White to off-white

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29726
Product name: IP7e
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29726
Product name: IP7e
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Tocris

Product number: 5699
Product name: IP7e
Purity: ≥98%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 5699
Product name: IP7e
Purity: ≥98%(HPLC)
Packaging: 50
Price: $774
Updated: 2021/12/16

Usbiological

Product number: 452435
Product name: IP7e
Packaging: 1mg
Price: $368
Updated: 2021/12/16

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IP7E Chemical Properties,Usage,Production

Uses

IP7e is an activator of Nurr1 signaling pathway.

Biological Activity

Cell permeable: yes', 'Primary Target
Nurr1/NR4A2

in vivo

IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process^[2].

Animal Model:	Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)^[2].
Dosage:	10 mg/kg
Administration:	Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i.
Result:	Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration.

IC 50

Nurr1/NR4A2

storage

Store at +4°C

IP7E Preparation Products And Raw materials

Raw materials

Preparation Products

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IP7E Suppliers

China 25 Japan 1 United Kingdom 1 United States 4 USA 1 Global 32

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11972
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 49551
Advantage: 58

500164-74-9, IP7ERelated Search:

IP7E

6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one

Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-

isoxazolo-pyridinone 7e

inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant

IP7e, 10 mM in DMSO

Nurr1 Activator, IP7e

500164-74-9