CD3 ANTIBODY
Source Reactivity Background References- Product Name
- CD3 ANTIBODY
- Chemical Name
- CD3 ANTIBODY
- CBNumber
- CB34734672
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb11921
- Product name
- CD3 antibody
- Purity
- Affinity purified
- Packaging
- 100μg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- orb44593
- Product name
- CD3 antibody
- Packaging
- 0.1mg
- Price
- $312.8
- Updated
- 2021/12/16
- Product number
- orb44592
- Product name
- CD3 antibody
- Packaging
- 0.1mg
- Price
- $312.8
- Updated
- 2021/12/16
- Product number
- orb44337
- Product name
- CD3 antibody
- Packaging
- 0.1mg
- Price
- $351.9
- Updated
- 2021/12/16
- Product number
- orb44559
- Product name
- CD3 antibody
- Packaging
- 0.1mg
- Price
- $351.9
- Updated
- 2021/12/16
CD3 ANTIBODY Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse
Background
When T cells encounter antigens via the T cell receptor, information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery. This activation process depends mainly on CD3, a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: ζ, γ, ε, and δ. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif. Engagement of the TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and the p85 subunit of PI-3 kinase. TCR ligation also induces a conformational change in CD3ε, such that a proline region is exposed and then associates with the adaptor protein Nck.The CD3ζ invariant chain is a type-I transmembrane protein that exists in the TCR signaling complex as a disulfide-linked homodimer. The cytoplasmic tail of each CD3ζ monomer contains three distinct ITAM motifs, each containing two tyrosine residues. Phosphorylation of CD3ζ ITAM tyrosine residues, including Y142, is driven by recruitment of the Lck and Fyn tyrosine kinases to the TCR. Lck/Fyn-mediated ITAM phosphorylation creates docking sites that promote the SH2 domain-dependent recruitment and activation of Zap-70, which drives amplification of signaling events downstream of the TCR that facilitate T cell activation. Phosphorylation of a pool of p16 CD3ζ leads to the generation of p21 and p23 species, which differ in the degree of ITAM phosphorylation. It has been proposed that the ratio of p21/p23 contributes to regulating the amplitude of T cell activation. CD3ζ plays an important role in the assembly and surface expression of the TCR complex. Indeed, research studies have demonstrated that CD3ζ is degraded in response to Ag-dependent TCR stimulation as a mechanism to tightly control T cell activation.
References
[1] Kuhns, M.S. et al. (2006) Immunity 24, 133-139.
[2] Pitcher, L.A. and van Oers, N.S. (2003) Trends Immunol. 24, 554-560.
[3] Osman, N. et al. (1996) Eur. J. Immunol. 26, 1063-1068.
[4] Hatada, M.H. et al. (1995) Nature 377, 32-38.
[5] Gil, D. et al. (2002) Cell 109, 901-912.
[6] Call, M.E. et al. (2006) Cell 127, 355-68.
[7] Housden, H.R. et al. (2003) Eur J Biochem 270, 2369-76.
[8] Hatada, M.H. et al. (1995) Nature 377, 32-8.
[9] Visco, C. et al. (2000) Biochemistry 39, 2784-2791.
[10] Iwashima, M. et al. (1994) Science 263, 1136-9.
CD3 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
CD3 ANTIBODY Suppliers
- Tel
- 13121935750
- jiaxin.zhao@acrobiosystems.com
- Country
- China
- ProdList
- 1361
- Advantage
- 58
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- 0755-26755892 1-949-553-1900
- international@genetex.com
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- China
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- 858.663.9055 8586639055
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- China
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- 6941
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- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
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- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
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- 21-80243558 86218024
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- China
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- 4006-123-828 13162017139
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- Country
- China
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- 51288865780
- sales@biosynth.com
- Country
- China
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- 400-025-6535
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- Country
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- Info@leadingbiology.com
- Country
- China
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