ChemicalBook > CAS DataBase List > Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Product Name
Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
CAS No.
6386-38-5
Chemical Name
Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Synonyms
Metilox;3,5-Methyl Ester;ralox35;Methyl 3-(3;Methyl 3-(3,5-di-ter;Propofol Impurity 35;Propofol Related Compound 3;3,5-di-tert-butyl-4-hydroxyphenyl;METHYL DI-t-BUTYL HYDROXYHYDROCINNAMATE;methyl di-tert-butyl hydroxyhydrocinnamate
CBNumber
CB3475740
Molecular Formula
C18H28O3
Formula Weight
292.41
MOL File
6386-38-5.mol
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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Property

Melting point:
60-67°C
Boiling point:
125-130 °C(Press: 0.1 Torr)
Density 
1.006±0.06 g/cm3(Predicted)
refractive index 
1.5034
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
12.17±0.40(Predicted)
color 
White to Almost white
Water Solubility 
2.2mg/L at 20℃
InChI
InChI=1S/C18H28O3/c1-17(2,3)13-10-12(8-9-15(19)21-7)11-14(16(13)20)18(4,5)6/h10-11,20H,8-9H2,1-7H3
InChIKey
PXMJCECEFTYEKE-UHFFFAOYSA-N
SMILES
C1(CCC(OC)=O)=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
LogP
4.866 (est)
CAS DataBase Reference
6386-38-5(CAS DataBase Reference)
EPA Substance Registry System
Methyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate (6386-38-5)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2918290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1810
Product name
Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging
5G
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
M1810
Product name
Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging
25G
Price
$44
Updated
2025/07/31
TRC
Product number
M301178
Product name
Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging
50g
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70028
Product name
3,5-di-tert-Butyl-4-hydroxyphenylpropionic acid methyl ester
Packaging
100g
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
045916
Product name
Methyl 3-[3,5-di(tert-butyl)-4-hydroxyphenyl]-propanoate
Purity
95+%
Packaging
100g
Price
$130
Updated
2021/12/16
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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Chemical Properties,Usage,Production

Uses

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is an antioxidant that is used in polyethylene.

Definition

ChEBI: Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester is an alkylbenzene.

Synthesis

128-39-2

292638-85-8

6386-38-5

(1) 2,6-di-tert-butylphenol (20.6 g), zinc carbonate (mass ratio 1.5) and tributyltin acetate (0.072 g) were added to a three-necked flask fitted with a mechanical stirrer, a nitrogen introduction tube and a dropping funnel under nitrogen atmosphere. The mixture was melted under nitrogen protection and heating conditions to form a reaction system. (2) When the temperature of the reaction system rose to 70°C, methyl acrylate (8.24 g) was slowly added through a dropping funnel. After the dropwise addition was completed, the reaction was continued with stirring for 0.5 hours. The reaction temperature was then raised to 90 °C and maintained for 1 hour. After completion of the reaction, it was cooled to 80 °C and the reaction solution was adjusted to neutral with dilute hydrochloric acid to induce crystallization of the product. After filtration, methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate was obtained in 99% yield and 99.5% purity without recrystallization.

References

[1] Patent: CN108358781, 2018, A. Location in patent: Paragraph 0046-0049
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 8.2, p. 1677 - 1682
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, # 8, p. 1829 - 1835
[4] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 8.2, p. 1677 - 1682
[5] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, # 8, p. 1829 - 1835

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Suppliers

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View Lastest Price from Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-16
Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-21

6386-38-5, Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionateRelated Search:

Kresoxim-methyl Methanol Butylated hydroxyanisole Methyl propionate Butylated Hydroxytoluene METSULFURON METHYL tert-Butylchlorodiphenylsilane Methyl acrylate Methyl cellulose Bensulfuron methyl Methyl 3,5-dihydroxybenzoate Calcium Propionate Methylparaben Di-tert-butyl peroxide Methyl Methyl bromide Antioxidant 1035 Antioxidant 1010

  • 3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONIC ACID METHYL ESTER
  • Benzenepropanoicacid,3,5-bis(1,1-dimethylethyl)-4-hydroxy-,methylester
  • Hydrocinnamicacid,3,5-di-tert-butyl-4-hydroxy-,methylester
  • ralox35
  • METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMATE
  • METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONATE
  • METHYL 3-[3,5-DI(TERT-BUTYL)-4-HYDROXYPHENYL]PROPANOATE
  • METHYL 3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)PROPIONATE
  • 3,5-Methyl Ester
  • 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid methyl ester
  • 3-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER
  • Methyl 3-(3,5-tertbutyl-4-hydroxyphenyl)propionate
  • 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYBENZENEPROPIONIC ACID METHYL ESTER
  • Methyl-3(3,5-di-tert.-butyl-4-hydroxyphenyl)propionat
  • 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester
  • 3-(3,5-Ditert-butyl-4-hydroxyphenyl)propanoic acid methyl ester
  • 3-(4-Hydroxy-3,5-di-tert-butylphenyl)propanoic acid methyl ester
  • 3-(4-Hydroxy-3,5-di-tert-butylphenyl)propionic acid methyl ester
  • 3,5-bis(1,1-dimethylethyl)-4-hydroxy-benzenepropanoicacimethylester
  • METHY(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL) PROPIONATE
  • 3,5-Di-tert-butyl-4-hydroxybenzenepropionic acid methyl ester
  • 3-[4-Hydroxy-3,5-bis(tert-butyl)phenyl]propanoic acid methyl ester
  • 4-Hydroxy-3,5-bis(tert-butyl)benzenepropanoic acid methyl ester
  • methyl 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate
  • Methyl 3-(4-hydroxy-3,5-di-t-butylphenyl) propionate
  • Methyl 3-(3,5-di-ter
  • 3 - (3, 5-2 tertiary butyl - 4 - hydroxy phenyl) propionic acid Methyl ester
  • Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, >=99%
  • methyl di-tert-butyl hydroxyhydrocinnamate
  • Metilox
  • Propofol Related Compound 3
  • 5-di-tert-butyl-4-hydroxyphenyl)propionate
  • Methyl 3-(3
  • METHYL DI-t-BUTYL HYDROXYHYDROCINNAMATE
  • 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid me...
  • 3,5-di-tert-butyl-4-hydroxyphenyl
  • Propofol Impurity 35
  • Cefditoren Pivoxil Impurity 22 Sodium Salt
  • Methylβ-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
  • 6386-38-5
  • 6386-35-5
  • Carboxylic
  • Aromatic Esters
  • Industrial/Fine Chemicals