Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

Product Name: Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
CAS No.: 2021249-10-3
Chemical Name: Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
Synonyms: Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
CBNumber: CB34797732
Molecular Formula: C44H49Cl2NO7
Formula Weight: 774.78
MOL File: 2021249-10-3.mol

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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Property

solubility: DMF: soluble; DMSO: soluble; Methanol: soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30813
Product name: Vilanterol-d4 (triphenylacetate)
Packaging: 500μg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 30813
Product name: Vilanterol-d4 (triphenylacetate)
Packaging: 1mg
Price: $576
Updated: 2024/03/01

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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties,Usage,Production

Description

Vilanterol-d₄ is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β₂-adrenergic receptor (β₂-AR).¹ It selectively induces cAMP accumulation in CHO cells expressing the β₂-AR over the β₁- and β₃-ARs (EC₅₀ = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC₅₀ = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

References

1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010).

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Suppliers

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2021249-10-3, Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)Related Search:

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Vilanterol-d4 Triphenylacetate

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate

2021249-10-3