ChemicalBook > CAS DataBase List > Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

Product Name
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
CAS No.
2021249-10-3
Chemical Name
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
Synonyms
Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
CBNumber
CB34797732
Molecular Formula
C44H49Cl2NO7
Formula Weight
774.78
MOL File
2021249-10-3.mol
More
Less

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Property

solubility 
DMF: soluble; DMSO: soluble; Methanol: soluble
form 
A solid
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
30813
Product name
Vilanterol-d4 (triphenylacetate)
Packaging
500μg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
30813
Product name
Vilanterol-d4 (triphenylacetate)
Packaging
1mg
Price
$576
Updated
2024/03/01
More
Less

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties,Usage,Production

Description

Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

References

1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010).

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Suppliers

Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9919
Advantage
12
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
Advantage
58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Scinova Biotech(Guangzhou) Co., Ltd.
Tel
13268215580
Email
scinova_sales@163.com
Country
China
ProdList
7023
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-021-51600108 13062666369
Email
sales@chinaisotope.com
Country
China
ProdList
4271
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
30961
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19710
Advantage
58