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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Product Name
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
CAS No.
135716-09-5
Chemical Name
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Synonyms
Ethyl 1-Boc-4-piperidine ...;Ethyl N-Boc-4-piperidineacetate;Ethyl 1-Boc-4-piperidine acetate;1-Boc-4-piperidine ethyl acetate;N-BOC-4-ETHYL PIPERIDINECARBOXYLATE;Ethyl N-Boc-piperidine-4-acetate, 96%;tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidin-1-carboxylate;1-[(tert-butoxy)carbonyl]-4-ethylpiperidine-2-carboxylate;Ethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate;tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
CBNumber
CB3480283
Molecular Formula
C14H25NO4
Formula Weight
271.35
MOL File
135716-09-5.mol
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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Property

Melting point:
19.68° C (Predicted)
Boiling point:
339.2±15.0 °C(Predicted)
Density 
1.048±0.06 g/cm3(Predicted)
refractive index 
n20D 1.47 (Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-1?+-.0.40(Predicted)
form 
solid
Appearance
Colorless to light yellow Liquid
InChIKey
PQEXLIRUMIRSAL-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CBR01324
Product name
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
E925443
Product name
EthylN-Boc-piperidine-4-acetate
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
E925443
Product name
EthylN-Boc-piperidine-4-acetate
Packaging
250mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-2Z
Product name
Ethyl 1-Boc-4-piperidine acetate
Packaging
5G
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB125450
Product name
tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Packaging
500mg
Price
$75
Updated
2021/12/16
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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate is used as a building block for the synthesis of organic compounds and drugs.

Synthesis

135716-08-4

135716-09-5

Tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate (22 g, 81.8 mmol) was added to wet 10% Pd/C (2.2 g) and ethanol (160 mL), and the mixture was degassed and backfilled three times with hydrogen. The reaction mixture was stirred at room temperature for 2 h under the protection of a hydrogen balloon. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (22.5 g, 100% yield). The m/z (M-100) was 172.1 as detected by LRMS, which was consistent with the theoretical value of 172.1.

References

[1] Heterocycles, 2001, vol. 54, # 2, p. 747 - 755
[2] Patent: WO2018/68297, 2018, A1. Location in patent: Page/Page column 135; 136
[3] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 48
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 6, p. 641 - 644
[5] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 707 - 710

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Suppliers

China 96 India 5 Switzerland 1 United Kingdom 2 United States 12 Global 116
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.
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View Lastest Price from tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate manufacturers

Honest Joy Holdings Limited
Product
Ethyl N-BOC-piperidine-4-acetate 135716-09-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-01-25
Career Henan Chemical Co
Product
N-BOC-4-ETHYL PIPERIDINECARBOXYLATE 135716-09-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-10

135716-09-5, tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylateRelated Search:

4-FLUORO-1-(1,1-DIMETHYLETHYL)1,4-PIPERIDINEDICARBOXYLIC ACID-4-ETHYL ESTER Ethyl 1-Boc-4-iso-propyl-4-piperidinecarboxylate Ethyl N-Boc-4-methylpiperidine-4-carboxylate N-BOC-4-ETHYL PIPERIDINECARBOXYLATE Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate Ethyl N-Boc-4-(4-chlorobenzyl)piperidine-4-carboxylate ETHYL N-BOC-4-(4-FLUOROBENZYL)PIPERIDINE-4-CARBOXYLATE ETHYL N-BOC-4-BENZYLPIPERIDINE-4-CARBOXYLATE ETHYL N-BOC-4-(4-BROMOBENZYL)PIPERIDINE-4-CARBOXYLATE 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester 3-Oxo-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Ethyl Ester 1-tert-Butyl 4-ethyl 4-(iodomethyl)piperidine-1,4-dicarboxylate ETHYL N-BOC-4-(4-METHOXYBENZYL)PIPERIDINE-4-CARBOXYLATE 1,4-DI-BOC-PIPERIDINE-2-CARBOXYLIC ACID 1-TERT-BUTYL 4-ETHYL 4-(NAPHTHALEN-2-YLMETHYL)PIPERIDINE-1,4-DICARBOXYLATE 1-tert-Butyl-4-ethyl 4-(4-fluorophenylthio)piperidine-1,4-dicarboxylate AURORA KA-3050 1-TERT-BUTYL 4-ETHYL 4-(CYCLOPROPYLMETHYL)PIPERIDINE-1,4-DICARBOXYLATE

  • N-BOC-4-ETHYL PIPERIDINECARBOXYLATE
  • tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(SALTDATA: FREE)
  • Ethyl N-Boc-4-piperidineacetate
  • Ethyl 1-Boc-4-piperidine ...
  • Ethyl 1-Boc-4-piperidine acetate
  • 1-[(tert-butoxy)carbonyl]-4-ethylpiperidine-2-carboxylate
  • tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidin-1-carboxylate
  • 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, ethyl ester
  • 2-(1-tert-Butoxycarbonyl-4-piperidyl)acetic acid ethyl ester
  • 4-(2-ethoxy-2-keto-ethyl)piperidine-1-carboxylic acid tert-butyl ester
  • 4-(2-ethoxy-2-oxoethyl)-1-piperidinecarboxylic acid tert-butyl ester
  • ((Ethoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester
  • Ethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate
  • 1-[(1,1-dimethylethoxy)carbonyl]-4-Piperidineacetic acid ethyl ester
  • 1-Boc-4-piperidine ethyl acetate
  • tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
  • Ethyl N-Boc-piperidine-4-acetate, 96%
  • 135716-09-5