tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Product Name: tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
CAS No.: 135716-09-5
Chemical Name: tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Synonyms: Ethyl 1-Boc-4-piperidine ...;Ethyl N-Boc-4-piperidineacetate;Ethyl 1-Boc-4-piperidine acetate;1-Boc-4-piperidine ethyl acetate;N-BOC-4-ETHYL PIPERIDINECARBOXYLATE;Ethyl N-Boc-piperidine-4-acetate, 96%;tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidin-1-carboxylate;1-[(tert-butoxy)carbonyl]-4-ethylpiperidine-2-carboxylate;Ethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate;tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
CBNumber: CB3480283
Molecular Formula: C14H25NO4
Formula Weight: 271.35
MOL File: 135716-09-5.mol

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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Property

Melting point:: 19.68° C (Predicted)
Boiling point:: 339.2±15.0 °C(Predicted)
Density: 1.048±0.06 g/cm3(Predicted)
refractive index: n20D 1.47 (Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: -1+-.0.40(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: 1S/C14H25NO4/c1-5-18-12(16)10-11-6-8-15(9-7-11)13(17)19-14(2,3)4/h11H,5-10H2,1-4H3
InChIKey: PQEXLIRUMIRSAL-UHFFFAOYSA-N
SMILES: CCOC(=O)CC1CCN(CC1)C(=O)OC(C)(C)C

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01324
Product name: tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: E925443
Product name: EthylN-Boc-piperidine-4-acetate
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: E925443
Product name: EthylN-Boc-piperidine-4-acetate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-2Z
Product name: Ethyl 1-Boc-4-piperidine acetate
Packaging: 5G
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB125450
Product name: tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate is used as a building block for the synthesis of organic compounds and drugs.

Synthesis

135716-08-4

135716-09-5

Tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate (22 g, 81.8 mmol) was added to wet 10% Pd/C (2.2 g) and ethanol (160 mL), and the mixture was degassed and backfilled three times with hydrogen. The reaction mixture was stirred at room temperature for 2 h under the protection of a hydrogen balloon. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (22.5 g, 100% yield). The m/z (M-100) was 172.1 as detected by LRMS, which was consistent with the theoretical value of 172.1.

References

[1] Heterocycles, 2001, vol. 54, # 2, p. 747 - 755
[2] Patent: WO2018/68297, 2018, A1. Location in patent: Page/Page column 135; 136
[3] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 48
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 6, p. 641 - 644
[5] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 707 - 710

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Suppliers

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View Lastest Price from tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate manufacturers

Honest Joy Holdings Limited

Product: Ethyl N-BOC-piperidine-4-acetate 135716-09-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-01-25

Career Henan Chemical Co

Product: N-BOC-4-ETHYL PIPERIDINECARBOXYLATE 135716-09-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-10

135716-09-5, tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylateRelated Search:

4-FLUORO-1-(1,1-DIMETHYLETHYL)1,4-PIPERIDINEDICARBOXYLIC ACID-4-ETHYL ESTER Ethyl 1-Boc-4-iso-propyl-4-piperidinecarboxylate Ethyl N-Boc-4-methylpiperidine-4-carboxylate N-BOC-4-ETHYL PIPERIDINECARBOXYLATE Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate Ethyl N-Boc-4-(4-chlorobenzyl)piperidine-4-carboxylate ETHYL N-BOC-4-(4-FLUOROBENZYL)PIPERIDINE-4-CARBOXYLATE ETHYL N-BOC-4-BENZYLPIPERIDINE-4-CARBOXYLATE ETHYL N-BOC-4-(4-BROMOBENZYL)PIPERIDINE-4-CARBOXYLATE 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 4-ethyl ester 3-Oxo-Piperidine-1,4-Dicarboxylic Acid 1-Tert-Butyl Ester 4-Ethyl Ester 1-tert-Butyl 4-ethyl 4-(iodomethyl)piperidine-1,4-dicarboxylate ETHYL N-BOC-4-(4-METHOXYBENZYL)PIPERIDINE-4-CARBOXYLATE 1,4-DI-BOC-PIPERIDINE-2-CARBOXYLIC ACID 1-TERT-BUTYL 4-ETHYL 4-(NAPHTHALEN-2-YLMETHYL)PIPERIDINE-1,4-DICARBOXYLATE 1-tert-Butyl-4-ethyl 4-(4-fluorophenylthio)piperidine-1,4-dicarboxylate AURORA KA-3050 1-TERT-BUTYL 4-ETHYL 4-(CYCLOPROPYLMETHYL)PIPERIDINE-1,4-DICARBOXYLATE

N-BOC-4-ETHYL PIPERIDINECARBOXYLATE

tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(SALTDATA: FREE)

Ethyl N-Boc-4-piperidineacetate

Ethyl 1-Boc-4-piperidine ...

Ethyl 1-Boc-4-piperidine acetate

1-[(tert-butoxy)carbonyl]-4-ethylpiperidine-2-carboxylate

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidin-1-carboxylate

4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, ethyl ester

2-(1-tert-Butoxycarbonyl-4-piperidyl)acetic acid ethyl ester

4-(2-ethoxy-2-keto-ethyl)piperidine-1-carboxylic acid tert-butyl ester

4-(2-ethoxy-2-oxoethyl)-1-piperidinecarboxylic acid tert-butyl ester

((Ethoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester

Ethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate

1-[(1,1-dimethylethoxy)carbonyl]-4-Piperidineacetic acid ethyl ester

1-Boc-4-piperidine ethyl acetate

tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Ethyl N-Boc-piperidine-4-acetate, 96%

135716-09-5