Methyl D-valinate hydrochloride
- Product Name
- Methyl D-valinate hydrochloride
- CAS No.
- 7146-15-8
- Chemical Name
- Methyl D-valinate hydrochloride
- Synonyms
- D-VALINE METHYL ESTER HYDROCHLORIDE;H-D-Val-OMe;D-Val-OMe·HCl;H-D-VAL-OME HCL;D-VALINE-OME HCL;H-N-Me-Val-OH·HCl;D-VALINE METHYL ESTER HCL;METHYL D-VALINATE HYDROCHLORIDE;O-Methyl-D-valine (hydrochloride);methyl 2-azanyl-3-methyl-butanoate
- CBNumber
- CB3482111
- Molecular Formula
- C6H14ClNO2
- Formula Weight
- 167.63
- MOL File
- 7146-15-8.mol
Methyl D-valinate hydrochloride Property
- Melting point:
- ~170 °C (dec.)
- alpha
- -15 º (c=2, H2O)
- refractive index
- -15 ° (C=2, H2O)
- storage temp.
- Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White
- optical activity
- [α]20/D 15.5±2°, c = 2% in H2O
- BRN
- 3912091
- InChI
- InChI=1/C6H13NO2.ClH/c1-4(2)5(7)6(8)9-3;/h4-5H,7H2,1-3H3;1H/t5-;/s3
- InChIKey
- KUGLDBMQKZTXPW-JEDNCBNOSA-N
- SMILES
- C(OC)(=O)[C@@H](C(C)C)N.[H]Cl |&1:4,r|
- CAS DataBase Reference
- 7146-15-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- HS Code
- 29241990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 94665
- Product name
- D-Valine methyl ester hydrochloride
- Purity
- ≥99.0% (AT)
- Packaging
- 5g
- Price
- $149
- Updated
- 2025/07/31
- Product number
- V0094
- Product name
- D-Valine Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 1g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- V0094
- Product name
- D-Valine Methyl Ester Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- V094335
- Product name
- D-Valine methyl ester hydrochloride
- Packaging
- 25g
- Price
- $405
- Updated
- 2021/12/16
- Product number
- 237269
- Product name
- D-Valine methyl ester hydrochloride 99+%
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
Methyl D-valinate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
D-Valine methyl ester hydrochloride is a protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
640-68-6
7146-15-8
The general procedure for the synthesis of D-valine methyl ester hydrochloride from methanol and D-valine was as follows: 8-10 mL of thionyl chloride was added slowly and dropwise to 100 mL of dry methanol suspension containing 5 g of D-valine at 0-5 °C. The reaction mixture continued to be stirred for 2 hours after the dropwise addition was completed, and was subsequently kept at 20-22°C for 24 hours to complete the reaction. After completion of the reaction, the solvent was removed by vacuum evaporation at 30-40°C. The residue was mixed with anhydrous ether and the product was separated by filtration, dried and recrystallized from the mixed methanol-ether solvent to give D-valine methyl ester hydrochloride. The yield of this synthesis step was 75% and the product had a melting point of 155-156°C and a specific spin of -15±1° (c=1.0, EtOH). Literature reports a specific spin of -15.5±2° (c=2.0,2). Infrared spectra (cm-1) showed characteristic absorption peaks located at 1730 and 1575.
References
[1] Tetrahedron, 1989, vol. 45, # 17, p. 5641 - 5654
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2002, vol. 45, # 6, p. 449 - 470
[3] European Journal of Organic Chemistry, 2010, # 22, p. 4276 - 4287
[4] Journal of the American Chemical Society, 2013, vol. 135, # 19, p. 7235 - 7250
[5] Russian Journal of Bioorganic Chemistry, 2017, vol. 43, # 4, p. 456 - 462
Methyl D-valinate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl D-valinate hydrochloride manufacturers
- Product
- Methyl D-valinate hydrochloride 7146-15-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 50kg/month
- Release date
- 2023-01-09
- Product
- H-D-Val-OMe·HCl 7146-15-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-03
- Product
- Methyl D-valinate hydrochloride 7146-15-8
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-16