METHYL 3,5-DIMETHYLBENZOATE
- Product Name
- METHYL 3,5-DIMETHYLBENZOATE
- CAS No.
- 25081-39-4
- Chemical Name
- METHYL 3,5-DIMETHYLBENZOATE
- Synonyms
- RARECHEM AL BF 0341;METHYL 3,5-DIMETHYLBENZOATE;3,5-Dimethylbenzoic acid methyl;Methyl 3,5-dimethylbenzoate 98%;3,5-DIMETHYLBENZOIC ACID METHYL ESTER;Benzoic acid, 3,5-dimethyl-, methyl ester
- CBNumber
- CB3483961
- Molecular Formula
- C10H12O2
- Formula Weight
- 164.2
- MOL File
- 25081-39-4.mol
METHYL 3,5-DIMETHYLBENZOATE Property
- Melting point:
- 31-33 °C (lit.)
- Boiling point:
- 239-240 °C (lit.)
- Density
- 1.027 g/mL at 25 °C (lit.)
- refractive index
- 1.5160 (estimate)
- Flash point:
- 224 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
Safety
- WGK Germany
- 3
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 370215
- Product name
- Methyl 3,5-dimethylbenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $27.17
- Updated
- 2025/07/31
- Product number
- M303643
- Product name
- Methyl 3,5-dimethylbenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M303643
- Product name
- Methyl 3,5-dimethylbenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M303643
- Product name
- Methyl 3,5-dimethylbenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 1959AB
- Product name
- Methyl 3,5-dimethylbenzoate
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
METHYL 3,5-DIMETHYLBENZOATE Chemical Properties,Usage,Production
Uses
Methyl 3,5-dimethylbenzoate may be used in the preparation of four carbon isostere related to highly active 4-pyridinemethanols, which were subsequently evaluated for their antimalarial activity. It may be used in the total synthesis of (±)-indoxamycin B.
General Description
Methyl 3,5-dimethylbenzoate is an aromatic carboxylic acid ester. It was selected as ligand during monomer screening for the synthesis and investigation of various europium compounds containing pinacolyl methylphosphonate with different ligands. Methyl 3,5-dimethylbenzoate is reported as precursor of methyl-3,5-divinylbenzoate.
Synthesis
499-06-9
67-56-1
25081-39-4
Bromobenzene (0.125 g, 0.0081 mol) and 10% palladium carbon (50% wet, 0.2 g) were added to an autoclave with 3,5-dimethylbenzoic acid (1.0 g, 0.0081 mol) and methanol (3 mL). The autoclave was pressurized with nitrogen (1-2 bar) followed by the addition of hydrogen (1-2 bar) and adjusted to the desired hydrogen pressure (5-6 bar). The reaction mixture was heated to 55-60 °C and stirred at 300 rpm for 4 hours. Upon completion of the reaction, the catalyst was filtered through a bed of diatomaceous earth to remove the catalyst. Water (30 mL) was added to the filtrate and the reaction mixture was extracted with isopropyl acetate (2 x 15 mL). The organic layers were combined, washed with 5% aqueous sodium bicarbonate (2 × 15 mL), dried over anhydrous Na2SO4 and filtered. Finally, the filtrate was evaporated by vacuum to give methyl 3,5-dimethylbenzoate product.
References
[1] Helvetica Chimica Acta, 1996, vol. 79, # 7, p. 1967 - 1979
[2] Journal of Organic Chemistry, 2006, vol. 71, # 19, p. 7205 - 7213
[3] Monatshefte fur Chemie, 1996, vol. 127, # 2, p. 185 - 200
[4] European Journal of Organic Chemistry, 2009, # 26, p. 4480 - 4485
[5] Tetrahedron Letters, 2013, vol. 54, # 42, p. 5690 - 5694
METHYL 3,5-DIMETHYLBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3,5-DIMETHYLBENZOATE manufacturers
- Product
- METHYL 3,5-DIMETHYLBENZOATE 25081-39-4
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10