ChemicalBook > CAS DataBase List > ACETARSONE

ACETARSONE

Product Name
ACETARSONE
CAS No.
97-44-9
Chemical Name
ACETARSONE
Synonyms
svc;190f;f190;goyl;mexyl;amasan;Oracid;Amassn;Qsarsal;Qrarsan
CBNumber
CB3485369
Molecular Formula
C8H10AsNO5
Formula Weight
275.09
MOL File
97-44-9.mol
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ACETARSONE Property

Melting point:
220.5°C
Boiling point:
72.17°C
Density 
1.0325 g/cm3(Temp: 15 °C)
storage temp. 
Store at RT
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
solid
pka
pKa 3.73 (H2O t=26) (Uncertain);7.9 (Uncertain); 9.3(H2O) (Uncertain)
color 
Crystalline material
Merck 
13,53
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Safety

Hazard Codes 
T,N
Risk Statements 
23/25-50/53
Safety Statements 
20/21-28-45-60-61
RIDADR 
UN 3465 6.1/PG 2
WGK Germany 
3
RTECS 
CF8400000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A188083
Product name
Acetarsone
Packaging
5g
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA01540
Product name
Acetarsol
Packaging
50g
Price
$235
Updated
2021/12/16
ApexBio Technology
Product number
A8355
Product name
Acetarsone
Packaging
1g
Price
$282
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA01540
Product name
Acetarsol
Packaging
100g
Price
$405
Updated
2021/12/16
AK Scientific
Product number
7891AF
Product name
Acetarsone
Packaging
100g
Price
$572
Updated
2021/12/16
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ACETARSONE Chemical Properties,Usage,Production

Chemical Properties

White prismatic crystal, odorless. Melting point 240-250°C (decomposition). Slightly soluble in cold water, ethanol and dilute acid, soluble in boiling water, caustic alkali solution or carbonate alkali solution. Stable at room temperature. Saturated aqueous solution shows acidic reaction to litmus.

Originator

Acetarsol ,Cyklo Pharma Chem Pvt. Ltd.

Uses

antiprotozoal; diethylamine salt as antiphilitic

Definition

ChEBI: Acetarsol is a member of acetamides and an anilide.

Manufacturing Process

1 part of 4-chloroaniline is dissolved with 2 parts of concentrated hydrochloric acid (specific gravity 1.16) and 10 parts of water, and diazotised in the usual manner. 3 parts of sodium arsenite are introduced into the diazo solution thus obtained, the sodium arsenite being dissolved in 5 parts of water and 1 part of 96% ethanol. The solution is heated slowly to 70°C. When evolution of nitrogene ceased, it is filtered from separated oil and the addition of hydrochloric acid precipitates the 4-chlorophenylarsonic acid, which crystallizes out in the form of white needles.
By action HNO3/H2SO4 on 4-chlorophenylarsonic acid is obtained 4-chloro-3- nitrophenylarsonic acid which is converted at 100°C with 33% aqueous solution of sodium hydroxide to 4-hydroxy-3-nitrophenylarsonic acid. After reduction of NO2 group of 4-hydroxy-3-nitrophenylarsonic acid by the action of Na2S2O3 or Fe/NaOH is obtained 3-amino-4-hydroxyphenylarsonic acid. From 3-amino-4-hydroxyphenylarsonic acid and acetic anhydride is prepared N-acetyl-4-hydroxy-m-arsanilic acid.

brand name

190 f;Acetarsolum;Amarson;Arsabott;Auryphan;Chrlich 594;Collarsin;Edoiacolo;Ehrlich 594;F 190;Fluryl;Fourneau 190;Kharophene;Neo-vagex;Pallacid;Trichovan;Vagipurin;Vagisep;Vagival.

Therapeutic Function

Antiprotozoal, Tonic

World Health Organization (WHO)

Acetarsol, which has antiprotozoal and antitrichomonal activity, has largely been discarded for systemic use because of its potential to cause systemic poisoning. However, topical preparations for vaginal trichomoniasis are still available and it is included in low concentrations (equal to or less than 0.45%) in some medicated toothpastes.

Safety Profile

Poison by ingestion and intravenous routes. Human systemic effects by ingestion: respiratory system, endocrine system, dermatitis, and fever. Human systemic effects by intravagmal route: hallucinations, dlstorted perceptions, convulsions, nausea or vomiting, decreased urine volume, and fever. Mutation data reported. See also ARSENIC COMPOUNDS. When heated to decomposition it emits very toxic fumes of NOx, and As

Purification Methods

It crystallises from water in colourless prisms. It decomposes slowly on prolonged boiling in H2O or dilute alkalis. The N-propionyl derivative recrystallises from H2O with m 228-229o(dec). [Raiziss & Fisher J Am Chem Soc 48 1323 1926, Hewitt & King J Chem Soc 823 1926, Beilstein 16 I 491, 16 II 521, 16 III 1129.]

ACETARSONE Preparation Products And Raw materials

Raw materials

Congo red paper 3-amino-4-hydroxyphenylarsonic acid

Preparation Products

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ACETARSONE Suppliers

China 49 France 1 Germany 1 India 3 Switzerland 1 United Kingdom 4 United States 15 Global 74
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View Lastest Price from ACETARSONE manufacturers

Dideu Industries Group Limited
Product
ACETARSONE 97-44-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

97-44-9, ACETARSONERelated Search:

Axitinib Sodium acetarsone,Acetarsone sodium Arecoline acetarsone METHYLARSONIC ACID Phenylarsine oxide 3-amino-4-hydroxyphenylarsonic acid Phenylarsine oxophenarsine PHENYLARSONIC ACID 2-Acetamidophenol ACETARSONE methyloxoarsine ARSINE 4-HYDROXYPHENYLARSONIC ACID 2-HYDROXYFORMANILIDE methanearsonous acid

  • paaroxyl
  • stovarsole
  • acetphenarine
  • amasan
  • ethrlich594
  • Acetarsone;Devegan;Qrarsan;Qsarsal;Osarsol;Osvarsan;Paroxyl;Sanogyl;Spirocid;S.V.C;Monargan;Kharophen
  • Qrarsan
  • Qsarsal
  • Spirocid
  • 3-Acetylamino-4-hydroxyphenyl-1-arsonic acid
  • N-ACETYL-4-HYDROXY-M-ARSANILICACID,ANHYDROUS
  • N-ACETYL-4-HYDROXY-META-ARSANILICACID
  • META-ARSANILICACID,N-ACETYL-4-HYDROXY-
  • Oracid
  • 3-ACETAMINO-4-HYDROXYPHENYLARSONIC ACID
  • N-ACETYL-4-HYDROXY-M-ARSANILIC ACID
  • (3-(acetylamino)-4-hydroxyphenyl)-arsonicaci
  • 190f
  • amarsan
  • Amassn
  • amoebal
  • arsaphen
  • arsonine
  • chrlich594
  • devegan
  • disparicida
  • dynarsan
  • ehrlich594
  • f190
  • fourneau190
  • ginarsol
  • goyl
  • gynoplix
  • kharophen
  • kubarsol
  • limarsol
  • malagride
  • mexyl
  • monargan
  • n-acetyl-4-hydroxy-m-arsanilicaci
  • nilacid
  • oralcid
  • orarsan
  • osarsal
  • osarsol
  • osarsole
  • osvarsan
  • pallicid
  • paroxyl
  • sanogyl
  • spirozid
  • stovarsol
  • stovarsolan
  • svc
  • vagisept
  • vagoflor
  • acetarson
  • 2-ACETYLAMINOPHENOL-4-ARSONIC ACID