ACETARSONE
- Product Name
- ACETARSONE
- CAS No.
- 97-44-9
- Chemical Name
- ACETARSONE
- Synonyms
- svc;190f;f190;goyl;mexyl;amasan;Oracid;Amassn;Qsarsal;Qrarsan
- CBNumber
- CB3485369
- Molecular Formula
- C8H10AsNO5
- Formula Weight
- 275.09
- MOL File
- 97-44-9.mol
ACETARSONE Property
- Melting point:
- 220.5°C
- Boiling point:
- 72.17°C
- Density
- 1.0325 g/cm3(Temp: 15 °C)
- storage temp.
- Store at RT
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- form
- solid
- pka
- pKa 3.73 (H2O t=26) (Uncertain);7.9 (Uncertain); 9.3(H2O) (Uncertain)
- color
- Crystalline material
- Merck
- 13,53
Safety
- Hazard Codes
- T,N
- Risk Statements
- 23/25-50/53
- Safety Statements
- 20/21-28-45-60-61
- RIDADR
- UN 3465 6.1/PG 2
- WGK Germany
- 3
- RTECS
- CF8400000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A188083
- Product name
- Acetarsone
- Packaging
- 5g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FA01540
- Product name
- Acetarsol
- Packaging
- 50g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- A8355
- Product name
- Acetarsone
- Packaging
- 1g
- Price
- $282
- Updated
- 2021/12/16
- Product number
- FA01540
- Product name
- Acetarsol
- Packaging
- 100g
- Price
- $405
- Updated
- 2021/12/16
- Product number
- 7891AF
- Product name
- Acetarsone
- Packaging
- 100g
- Price
- $572
- Updated
- 2021/12/16
ACETARSONE Chemical Properties,Usage,Production
Originator
Acetarsol ,Cyklo Pharma Chem Pvt. Ltd.
Uses
antiprotozoal; diethylamine salt as antiphilitic
Definition
ChEBI: Acetarsol is a member of acetamides and an anilide.
Manufacturing Process
1 part of 4-chloroaniline is dissolved with 2 parts of concentrated hydrochloric
acid (specific gravity 1.16) and 10 parts of water, and diazotised in the usual
manner. 3 parts of sodium arsenite are introduced into the diazo solution thus
obtained, the sodium arsenite being dissolved in 5 parts of water and 1 part
of 96% ethanol. The solution is heated slowly to 70°C. When evolution of
nitrogene ceased, it is filtered from separated oil and the addition of
hydrochloric acid precipitates the 4-chlorophenylarsonic acid, which
crystallizes out in the form of white needles.
By action HNO3/H2SO4 on 4-chlorophenylarsonic acid is obtained 4-chloro-3-
nitrophenylarsonic acid which is converted at 100°C with 33% aqueous
solution of sodium hydroxide to 4-hydroxy-3-nitrophenylarsonic acid. After
reduction of NO2 group of 4-hydroxy-3-nitrophenylarsonic acid by the action
of Na2S2O3 or Fe/NaOH is obtained 3-amino-4-hydroxyphenylarsonic acid.
From 3-amino-4-hydroxyphenylarsonic acid and acetic anhydride is prepared
N-acetyl-4-hydroxy-m-arsanilic acid.
brand name
190 f;Acetarsolum;Amarson;Arsabott;Auryphan;Chrlich 594;Collarsin;Edoiacolo;Ehrlich 594;F 190;Fluryl;Fourneau 190;Kharophene;Neo-vagex;Pallacid;Trichovan;Vagipurin;Vagisep;Vagival.
Therapeutic Function
Antiprotozoal, Tonic
World Health Organization (WHO)
Acetarsol, which has antiprotozoal and antitrichomonal activity, has largely been discarded for systemic use because of its potential to cause systemic poisoning. However, topical preparations for vaginal trichomoniasis are still available and it is included in low concentrations (equal to or less than 0.45%) in some medicated toothpastes.
Safety Profile
Poison by ingestion and intravenous routes. Human systemic effects by ingestion: respiratory system, endocrine system, dermatitis, and fever. Human systemic effects by intravagmal route: hallucinations, dlstorted perceptions, convulsions, nausea or vomiting, decreased urine volume, and fever. Mutation data reported. See also ARSENIC COMPOUNDS. When heated to decomposition it emits very toxic fumes of NOx, and As
Purification Methods
It crystallises from water in colourless prisms. It decomposes slowly on prolonged boiling in H2O or dilute alkalis. The N-propionyl derivative recrystallises from H2O with m 228-229o(dec). [Raiziss & Fisher J Am Chem Soc 48 1323 1926, Hewitt & King J Chem Soc 823 1926, Beilstein 16 I 491, 16 II 521, 16 III 1129.]
ACETARSONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ACETARSONE manufacturers
- Product
- ACETARSONE 97-44-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17