N-CBZ-4-PIPERIDINEACETIC ACID
- Product Name
- N-CBZ-4-PIPERIDINEACETIC ACID
- CAS No.
- 63845-28-3
- Chemical Name
- N-CBZ-4-PIPERIDINEACETIC ACID
- Synonyms
- N-CBZ-4-PIPERIDINEACETIC ACID;1-Cbz-4-Piperidineacetic acid;Cbz-1-piperidine-4-acetic acid;1-N-CBZ-4-PIPERIDINEACETIC ACID;2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid;2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid;2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
- CBNumber
- CB3489882
- Molecular Formula
- C15H19NO4
- Formula Weight
- 277.32
- MOL File
- 63845-28-3.mol
N-CBZ-4-PIPERIDINEACETIC ACID Property
- Boiling point:
- 460.1±28.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.66±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B194215
- Product name
- 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)aceticAcid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC140537
- Product name
- N-Cbz-4-piperidineacetic acid
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- FC140537
- Product name
- N-Cbz-4-piperidineacetic acid
- Packaging
- 5G
- Price
- $257
- Updated
- 2021/12/16
- Product number
- 119335
- Product name
- 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- FC140537
- Product name
- N-Cbz-4-piperidineacetic acid
- Packaging
- 10g
- Price
- $446.3
- Updated
- 2021/12/16
N-CBZ-4-PIPERIDINEACETIC ACID Chemical Properties,Usage,Production
Synthesis
501-53-1
73415-84-6
63845-28-3
For the preparation of 1-Cbz-4-piperidineacetic acid (compound 2), the method was modified as described in DE 4304650 A1. The procedure was as follows: 2-(piperidin-4-yl)acetic acid hydrochloride (3000 mg, 16.7 mmol; Iris Biotech, Marktredwitz, Germany) was dissolved in 46 mL of 1 M NaOH aqueous solution and cooled in an ice bath. Under stirring conditions, benzyloxycarbonyl chloride (Cbz-Cl, 3350 μL, 23.46 mmol, 4002 mg) was slowly added dropwise for a controlled time of 5 min. Subsequently, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the aqueous phase was washed twice with water (20 mL) and a solvent mixture of diethyl ether/petroleum ether (4:1, v/v), and then acidified to pH 1 with aqueous 4 M HCl. The reaction product was extracted with diisopropyl ether (3 × 50 mL). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 as a colorless solid (4383 mg, 15.8 mmol, 95% yield).1H NMR (400 MHz, CDCl3) δ 7.40-7.27 (m, 5H), 5.13 (s, 2H), 4.18 (d, J = 13.3 Hz, 2H), 2.81 ( t, J = 12.8 Hz, 2H), 2.29 (d, J = 7.0 Hz, 2H), 1.96 (tp, J = 11.2, 3.5 Hz, 1H), 1.75 (d, J = 12.1 Hz, 2H), 1.30-1.09 (m, 2H).
References
[1] Patent: WO2014/125084, 2014, A1. Location in patent: Page/Page column 33; 34
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00344; 00345; 00346
N-CBZ-4-PIPERIDINEACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-CBZ-4-PIPERIDINEACETIC ACID manufacturers
- Product
- N-CBZ-4-PIPERIDINEACETIC ACID 63845-28-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2019-08-05