ChemicalBook > CAS DataBase List > N-CBZ-4-PIPERIDINEACETIC ACID

N-CBZ-4-PIPERIDINEACETIC ACID

Product Name
N-CBZ-4-PIPERIDINEACETIC ACID
CAS No.
63845-28-3
Chemical Name
N-CBZ-4-PIPERIDINEACETIC ACID
Synonyms
N-CBZ-4-PIPERIDINEACETIC ACID;1-Cbz-4-Piperidineacetic acid;Cbz-1-piperidine-4-acetic acid;1-N-CBZ-4-PIPERIDINEACETIC ACID;2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid;2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid;2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
CBNumber
CB3489882
Molecular Formula
C15H19NO4
Formula Weight
277.32
MOL File
63845-28-3.mol
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N-CBZ-4-PIPERIDINEACETIC ACID Property

Boiling point:
460.1±28.0 °C(Predicted)
Density 
1.216±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.66±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B194215
Product name
2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)aceticAcid
Packaging
250mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140537
Product name
N-Cbz-4-piperidineacetic acid
Packaging
1g
Price
$74
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140537
Product name
N-Cbz-4-piperidineacetic acid
Packaging
5G
Price
$257
Updated
2021/12/16
Matrix Scientific
Product number
119335
Product name
2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid
Purity
95+%
Packaging
5g
Price
$432
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140537
Product name
N-Cbz-4-piperidineacetic acid
Packaging
10g
Price
$446.3
Updated
2021/12/16
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N-CBZ-4-PIPERIDINEACETIC ACID Chemical Properties,Usage,Production

Synthesis

501-53-1

73415-84-6

63845-28-3

For the preparation of 1-Cbz-4-piperidineacetic acid (compound 2), the method was modified as described in DE 4304650 A1. The procedure was as follows: 2-(piperidin-4-yl)acetic acid hydrochloride (3000 mg, 16.7 mmol; Iris Biotech, Marktredwitz, Germany) was dissolved in 46 mL of 1 M NaOH aqueous solution and cooled in an ice bath. Under stirring conditions, benzyloxycarbonyl chloride (Cbz-Cl, 3350 μL, 23.46 mmol, 4002 mg) was slowly added dropwise for a controlled time of 5 min. Subsequently, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the aqueous phase was washed twice with water (20 mL) and a solvent mixture of diethyl ether/petroleum ether (4:1, v/v), and then acidified to pH 1 with aqueous 4 M HCl. The reaction product was extracted with diisopropyl ether (3 × 50 mL). The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 as a colorless solid (4383 mg, 15.8 mmol, 95% yield).1H NMR (400 MHz, CDCl3) δ 7.40-7.27 (m, 5H), 5.13 (s, 2H), 4.18 (d, J = 13.3 Hz, 2H), 2.81 ( t, J = 12.8 Hz, 2H), 2.29 (d, J = 7.0 Hz, 2H), 1.96 (tp, J = 11.2, 3.5 Hz, 1H), 1.75 (d, J = 12.1 Hz, 2H), 1.30-1.09 (m, 2H).

References

[1] Patent: WO2014/125084, 2014, A1. Location in patent: Page/Page column 33; 34
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00344; 00345; 00346

N-CBZ-4-PIPERIDINEACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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N-CBZ-4-PIPERIDINEACETIC ACID Suppliers

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View Lastest Price from N-CBZ-4-PIPERIDINEACETIC ACID manufacturers

Career Henan Chemical Co
Product
N-CBZ-4-PIPERIDINEACETIC ACID 63845-28-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2019-08-05

63845-28-3, N-CBZ-4-PIPERIDINEACETIC ACIDRelated Search:

1-BOC-PIPERIDIN-4-YLIDENE-ACETIC ACID 1-Cbz-4-Piperidine Acetic Acid Ethyl Ester (R)-1-Cbz-3-Piperidineacetic Acid Methyl Ester 1-Cbz-3-Piperidineacetic Acid Methyl Ester,N-CBZ-3-PIPERIDINEACETIC ACID METHYL ESTER 1-Cbz-3-Piperidineacetic Acid,N-CBZ-3-PIPERIDINEACETIC ACID,1-N-CBZ-3-PIPERIDINEACETIC ACID (S)-1-Cbz-3-Piperidineacetic Acid Methyl Ester N-CBZ-2-PIPERIDINEACETIC ACID 4-(2-OXO-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER N-CBZ-4-PIPERIDINEACETIC ACID N-A-BOC-(4-N-CBZ-PIPERIDINYL) GLYCINE 1-CBZ-4-(2-HYDROXY-ETHYL)-PIPERIDINE BOC-(2S)-GLY-4PIP-Z N-CBZ-4-PIPERIDINEACETIC ACID METHYL ESTER

  • Cbz-1-piperidine-4-acetic acid
  • 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid
  • 2-(1-phenylmethoxycarbonylpiperidin-4-yl)acetic acid
  • N-CBZ-4-PIPERIDINEACETIC ACID
  • 1-N-CBZ-4-PIPERIDINEACETIC ACID
  • 1-Cbz-4-Piperidineacetic acid
  • 4-Piperidineacetic acid, 1-[(phenylmethoxy)carbonyl]-
  • 2-(1-benzyloxycarbonyl-4-piperidyl)acetic acid
  • 63845-28-3
  • pharmacetical