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Mizagliflozin

Product Name
Mizagliflozin
CAS No.
666843-10-3
Chemical Name
Mizagliflozin
Synonyms
KGA3235;KGA 3235;KGA-3235;GSK1614235;GSK-1614235;GSK 1614235;Mizagliflozin;DSP-3235 free base;KGA-3235 free base;GSK-1614235 free base
CBNumber
CB34919871
Molecular Formula
C28H44N4O8
Formula Weight
564.68
MOL File
666843-10-3.mol
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Mizagliflozin Property

Boiling point:
837.0±65.0 °C(Predicted)
Density 
1.274±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Methanol: 250 mg/mL (442.74 mM); DMSO: 100 mg/mL (177.09 mM)
form 
Solid
pka
12.65±0.70(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016832
Product name
Mizagliflozin
Purity
99.64%
Packaging
5mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0016832
Product name
Mizagliflozin
Purity
99.64%
Packaging
10mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-0016832
Product name
Mizagliflozin
Purity
99.64%
Packaging
25mg
Price
$1600
Updated
2021/12/16
ChemScene
Product number
CS-0016832
Product name
Mizagliflozin
Purity
99.64%
Packaging
50mg
Price
$2500
Updated
2021/12/16
ChemScene
Product number
CS-0016832
Product name
Mizagliflozin
Purity
99.64%
Packaging
100mg
Price
$4000
Updated
2021/12/16
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Mizagliflozin Chemical Properties,Usage,Production

Uses

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1].

in vivo

Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect[1].
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)[2]

Animal Model:Male Wistar rats (rat model of low-fiber-diet-induced constipation)[1]
Dosage:3, 10, 30 mg/kg
Administration:Oral
Result:Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.

IC 50

SGLT1

References

[1] Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. DOI:10.1016/j.ejphar.2017.04.010
[2] Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. DOI:10.1080/00498254.2018.1449269

Mizagliflozin Preparation Products And Raw materials

Raw materials

Preparation Products

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Mizagliflozin Suppliers

China 37 United States 4 Global 41
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

666843-10-3, MizagliflozinRelated Search:


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