ChemicalBook > CAS DataBase List > 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Product Name
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
CAS No.
60611-24-7
Chemical Name
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
Synonyms
OTF-BAD-6F;4-Fluoro-5'-hydroxybenzopheone;2-Fluoro-6-trifluorobenzaldehyde;α,α,α,6-Tetrafluoro-o-tolualdehyde;α,α,α,6-Tetrafluoro-2-tolualdehyde;à,à,à,6-tetrafluoro-o-tolualdehyde;2-fluoro-6-(trifluoromethyl)benzald;2-Fluor-6-trifluormethylbenzaldehyd;2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE;Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-
CBNumber
CB3492563
Molecular Formula
C8H4F4O
Formula Weight
192.11
MOL File
60611-24-7.mol
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2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Property

Melting point:
155-157°C
Boiling point:
156 °C (lit.)
Density 
1.432 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.458(lit.)
Flash point:
179 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Almost colorless
Sensitive 
Air Sensitive
BRN 
2263481
InChI
InChI=1S/C8H4F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-4H
InChIKey
FAKUGVHRTLCKHB-UHFFFAOYSA-N
SMILES
C(=O)C1=C(C(F)(F)F)C=CC=C1F
CAS DataBase Reference
60611-24-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
436089
Product name
2-Fluoro-6-(trifluoromethyl)benzaldehyde
Purity
98%
Packaging
1g
Price
$38
Updated
2023/01/07
TCI Chemical
Product number
F1033
Product name
2-Fluoro-6-(trifluoromethyl)benzaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
F1033
Product name
2-Fluoro-6-(trifluoromethyl)benzaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$136
Updated
2025/07/31
TRC
Product number
F599048
Product name
2-Fluoro-6-(trifluoromethyl)benzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
002739
Product name
2-Fluoro-6-(trifluoromethyl)benzaldehyde
Purity
97%
Packaging
5g
Price
$41
Updated
2021/12/16
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2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production

Uses

2-Fluoro-6-(trifluoromethyl)benzaldehyde may be employed for the synthesis of diaryl ether, 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)- benzonitrile and substituted benzo[b]thiophene-2-carboxylates.

General Description

2-Fluoro-6-(trifluoromethyl)benzaldehyde participates in the synthesis of 2-amino-5-trifluoromethylquinazoline.

Synthesis

401-80-9

68-12-2

60611-24-7

In a 5L three-necked round-bottomed flask, 3-fluorobenzotrifluoride (492.0 g, 3.0 mol), N,N,N',N'-tetramethylethylenediamine (TMEDA, 383.2 g, 3.3 mol), diisopropylamine (DIPA, 21.3 g, 0.16 mol), and anhydrous tetrahydrofuran (THF, 1.5 L) were added and the reaction system was cooled to -70 to - 78 °C. A solution of n-butyllithium (n-BuLi, 211.5 g, 3.3 mol) was slowly added dropwise at -70 to -78 °C. The reaction was maintained at this temperature for 2 to 3 hours. Subsequently, N,N-dimethylformamide (DMF, 328.7 g, 4.5 mol) was slowly added and the reaction was continued at this temperature for 1-2 hours. After completion of the reaction, it was slowly warmed up to room temperature, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution (500 ml) and extracted with ethyl acetate (500 ml x 3). The organic layers were combined and concentrated to dryness to give 510.1 g of the solid product 2-fluoro-6-trifluoromethylbenzaldehyde in 88.7% yield.

References

[1] Patent: CN107935863, 2018, A. Location in patent: Paragraph 0040-0043; 0053-0054; 0060-0061
[2] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[3] Tetrahedron Letters, 2013, vol. 54, # 45, p. 6053 - 6056

2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Suppliers

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View Lastest Price from 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE 60611-24-7
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-13
Career Henan Chemical Co
Product
2-Fluoro-6-(trifluoromethyl)benzaldehyde 60611-24-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

60611-24-7, 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDERelated Search:

2'-FLUORO-6'-(TRIFLUOROMETHYL)ACETOPHENONE 2-FLUORO-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 3-CHLORO-2-FLUORO-6-(TRIFLUOROMETHYL)BENZOIC ACID 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE 2-FLUORO-6-(TRIFLUOROMETHYL)BENZOPHENONE 2-FLUORO-6-(TRIFLUOROMETHYL)BENZOIC ACID 3-CHLORO-2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE,3-Chloro-2-fluoro-6-(trifluoromethyl)benzaldehyde, 97+% 3-CHLORO-2-FLUORO-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 5-FLUORO-2-(TRIFLUOROMETHYL)BENZALDEHYDE,5-Fluoro-2-(trifluoromethyl)benzaldehyde 97%,5-Fluoro-2-(trifluoromethyl)benzaldehyde97% 3,4-DIFLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE 3-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE,3-Fluoro-5-(trifluoromethyl)benzaldehyde97%,3-Fluoro-5-(trifluoromethyl)benzaldehyde 97% 2-Fluoro-4-(trifluoromethyl)benzaldehyde97%,2-Fluoro-4-(trifluoromethyl)benzaldehyde 97%,2-FLUORO-4-(TRIFLUOROMETHYL)BENZALDEHYDE 2-Fluoro-5-(trifluoromethyl)benzaldehyde 97%,2-Fluoro-5-(trifluoromethyl)benzaldehyde97%,2-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE 4-Fluoro-2-(trifluoromethyl)benzaldehyde 4-FLUORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE,4-Fluoro-3-(trifluoromethyl)benzaldehyde 97%,4-Fluoro-3-(trifluoromethyl)benzaldehyde97% 3-Fluoro-4-(trifluoromethyl)benzaldehyde 97%,3-Fluoro-4-(trifluoromethyl)benzaldehyde97%,3-FLUORO-4-(TRIFLUOROMETHYL)BENZALDEHYDE 2,3-Difluoro-4-(trifluoromethyl)benzaldehyde

  • 2-Fluoro-6-trifluorobenzaldehyde
  • 2-Fluoro-6-(trifluoromethyl)benzaldehyde 97%
  • 2-Fluoro-6-(trifluoromethyl)benzaldehyde97%
  • α,α,α,6-Tetrafluoro-2-tolualdehyde
  • α,α,α,6-Tetrafluoro-o-tolualdehyde
  • 3-Fluoro-2-formylbenzotrifluoride, alpha,alpha,alpha,6-Tetrafluoro-o-tolualdehyde
  • 2-Fluor-6-trifluormethylbenzaldehyd
  • 2-fluoro-6-(trifluoromethyl)benzald
  • Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-
  • OTF-BAD-6F
  • 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
  • alpha,alpha,alpha,6-Tetrafluoro-o-tolualdehyde
  • à,à,à,6-tetrafluoro-o-tolualdehyde
  • 2-Fluoro-6-(trifluoromethyl)benzaldehyde&gt
  • 4-Fluoro-5'-hydroxybenzopheone
  • 60611-24-7
  • ALDEHYDE
  • Building Blocks
  • Carbonyl Compounds
  • C8
  • Organic Building Blocks
  • Aldehydes
  • Fluorine series
  • Benzaldehyde
  • Aldehydes
  • C8
  • Carbonyl Compounds