ChemicalBook > CAS DataBase List > 1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one

Product Name
1,4-Dioxaspiro[4.5]decan-8-one
CAS No.
4746-97-8
Chemical Name
1,4-Dioxaspiro[4.5]decan-8-one
Synonyms
1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;cyclohexanedione monoethylene ketal;1,4-Cyclohexanedione ethylene ketal;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one;1,4-Dioxiro[4.5]decan-8-one.;1,4-Cyclohexanedion Monoethyl
CBNumber
CB3496677
Molecular Formula
C8H12O3
Formula Weight
156.18
MOL File
4746-97-8.mol
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1,4-Dioxaspiro[4.5]decan-8-one Property

Melting point:
70-73 °C (lit.)
Boiling point:
112C
Density 
1.0887 (rough estimate)
refractive index 
1.4430 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in chloroform & methanol.
form 
Crystalline Powder or Crystals
color 
White to beige
Sensitive 
Moisture Sensitive
BRN 
117631
InChI
InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKey
VKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILES
O1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference
4746-97-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
F 
8-10-21
Hazard Note 
Irritant
HS Code 
29110000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
274879
Product name
1,4-Cyclohexanedione monoethylene acetal
Purity
97%
Packaging
5g
Price
$42
Updated
2024/03/01
Sigma-Aldrich
Product number
274879
Product name
1,4-Cyclohexanedione monoethylene acetal
Purity
97%
Packaging
25g
Price
$77.6
Updated
2024/03/01
TCI Chemical
Product number
C1292
Product name
1,4-Cyclohexanedione Monoethyleneketal
Purity
>98.0%(GC)
Packaging
5g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
C1292
Product name
1,4-Cyclohexanedione Monoethyleneketal
Purity
>98.0%(GC)
Packaging
25g
Price
$42
Updated
2024/03/01
Alfa Aesar
Product number
A10408
Product name
1,4-Cyclohexanedione monoethylene acetal, 97%
Packaging
5g
Price
$40.65
Updated
2024/03/01
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1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Usage,Production

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Dioxaspiro[4.5]decan-8-one Suppliers

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View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

Speranza Chemical Co., Ltd.
Product
1,4-Cyclohexanedione monoethyleneacetal 4746-97-8
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300 Tons/ year
Release date
2019-12-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-18
Xi'an Tuochao Biotechnology Co., Ltd
Product
1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
1T
Release date
2023-02-08

4746-97-8, 1,4-Dioxaspiro[4.5]decan-8-oneRelated Search:

Diethylene glycol DIOXOPROMETHAZINE HCL 2-Bromomethyl-1,3-dioxolane Decane Cyclohexanone 1,4-Cyclohexanedione Buspirone Selenium dioxide 1,4-Dioxane 2,2-DIMETHYL-1,3-DIOXOLANE 4-HYDROXYCYCLOHEXANONE 1,1-DIMETHOXYCYCLOHEXANE 2-METHYL-1,3-DIOXOLANE DIOXOPROMETHAZINE HEXANAL DIMETHYL ACETAL 1,3-Dioxolane 2-ETHYL-2-METHYL-1,3-DIOXOLANE 3,3-DIMETHOXYHEXANE

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  • 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL (1,4-DIOXASPIRO(4.5)DECAN-8-ONE)
  • 1,4-Dioxaspiro[4.5]decan-8-one, Cyclohexane-1,4-dione monoethylene ketal
  • Cyclohexane-1,4-dione monoethylene acetal
  • KEHK
  • 1,4-Dioxaspiro[4.5]decan-8-one ,99%
  • 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL
  • 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL
  • 1,4-DIOXASPIRO[4.5]DECAN-8-ONE
  • 1,4-DIOXASPIRO[4.5]-8-DECANONE
  • CYCLOHEXANEDIONE(1,4-) MONOETHYLENE
  • 4-Cyclohexanedione Monoethylene acetal
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  • 1,4-Cyclohexanedion Monoethyl
  • 1,4-Dioxaspiro[4.5]decan-8-one, 98% 25GR
  • Cyclohexane-1,4-dione monoethylene ketal, 8-Oxo-1,4-dioxaspiro[4.5]decane
  • Ethylene glycolcyclohexanoneketalsingleloop 1,4-
  • 1,4-Cyclohexanedione Monoethylene acetal 97%
  • 1,4-Dioxaspiro[4.5]decan-8-one, 95+%
  • 1,4-Dioxaspiro[4.5]decane-8-one-
  • 4,4-(Ethylenebisoxy)cyclohexan-1-one
  • 7,10-Dioxaspiro[5.4]decane-3-one
  • Spiro[cyclohexane-1,2'-1,3-dioxolane]-4-one
  • 1,4-Cyclohexanedione monoethylene acetal (1,4-Dioxaspiro(4 x 5)d
  • Cyclohexanedione monoethyleneacetal
  • 1,4-Dioxaspiro[4.5]decan-8-one,98%
  • 1, 4 - cyclohexanol diketone glycol ketal
  • 1,4-Dioxaspiro[4,5!decan-8-one, 97+%
  • Cyclohexane-1,4-dione monoethylene acetal 99%
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  • 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)
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  • 1,4-Dioxaspiro[4.5]decan-8-one (6CI, 7CI, 8CI, 9CI, ACI)
  • 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL > 97% puriss for synthesis
  • 1,4-Cyclohexanedione monoethylene
  • cyclohexanedione monoacetal
  • 4746-97-8
  • 4740-97-8
  • C8H12O3
  • Acetals/Ketals/Ortho Esters
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