R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST
- Product Name
- R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST
- CAS No.
- 125-58-6
- Chemical Name
- R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST
- Synonyms
- levothyl;l-polamivet;levomethadone;(R)-Methadone;(-)-Diaminone;Laevomethadon;(6r)-methadone;4-diphenyl-6-(dimethylamino)-l-3-heptanon;4-diphenyl-6-(dimethylamino)-(r)-3-hetpanon;R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST
- CBNumber
- CB3498242
- Molecular Formula
- C21H27NO
- Formula Weight
- 309.44518
- MOL File
- 125-58-6.mol
R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST Property
- Melting point:
- 99°C
- Boiling point:
- 449.71°C (rough estimate)
- Density
- 1.0350 (rough estimate)
- refractive index
- 1.5614 (estimate)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H336May cause drowsiness or dizziness
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
R(-)-METHADONE HYDROCHLORIDE OPIOID AGON IST Chemical Properties,Usage,Production
Definition
ChEBI: Levomethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine. It has a role as an antitussive, an opioid analgesic, a mu-opioid receptor agonist and a NMDA receptor antagonist. It is an enantiomer of a dextromethadone.
Purification Methods
This pharmacologically active (against narcotic addiction) enantiomer was obtained by optical resolution (using D-tartaric acid) of the racemate and was purified by precipitation of the hydrochloride from aqueous solution at pH >6, dried and recrystallised from propan-2-ol. The R-hydrochloride [5967-73-7], when recrystallised from propan-2-ol, has m 245-246o, [] D 20 -169o (c 2, EtOH). The S-(+)-enantiomer [5653-8-5] also recrystallises from propan-2-ol and has recorded m of 100-101o, [] D 25 + 26o (c 1.2, H2O). The S-hydrochloride [15284-15-8], when crystallised from propan-2-ol, has m 243-244o, [] D 20 +169o (c 2, EtOH). [Larsen et al. J Am Chem Soc 70 4194 1948, Brode & Hill J Org Chem 13 191 1948, Schultz et al. J Am Chem Soc 69 2454 1947, Easton et al. J Am Chem Soc 69 2941 1947, Winter & Flataker J Pharmacol Exp Ther 98 305 1950, Beilstein 14 III 278, 1 4 III/IV 300.]