Methyl 2,6-dichloronicotinate
- Product Name
- Methyl 2,6-dichloronicotinate
- CAS No.
- 65515-28-8
- Chemical Name
- Methyl 2,6-dichloronicotinate
- Synonyms
- METHYL 2,6-DICHLORONICOTINATE;2,6-two chloroMethyl nicotinate;Methyl2,6-dichloronicotinate,97%;Methyl 2,6-Dichloronicotinate >methyl 2,6-dichloronicotinate (en);METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA&;Methyl 2,6-dichloropyridin-3-carboxylate;Methyl 2,6-Dichloro-3-pyridinecarboxylate;2,6-Dichloropyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-, methyl ester
- CBNumber
- CB3500167
- Molecular Formula
- C7H5Cl2NO2
- Formula Weight
- 206.03
- MOL File
- 65515-28-8.mol
Methyl 2,6-dichloronicotinate Property
- Melting point:
- 56-60 °C(lit.)
- Boiling point:
- 270.5±35.0 °C(Predicted)
- Density
- 1.426±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- -4.55±0.10(Predicted)
- color
- White to Light yellow
- Sensitive
- Air Sensitive
- λmax
- 276nm(lit.)
- InChI
- InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-2-3-5(8)10-6(4)9/h2-3H,1H3
- InChIKey
- IFVVGOJYWCHRCT-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC=C1C(OC)=O
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 656437
- Product name
- Methyl 2,6-dichloropyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $95.1
- Updated
- 2023/01/07
- Product number
- M2616
- Product name
- Methyl 2,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- M2616
- Product name
- Methyl 2,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- M301385
- Product name
- Methyl 2,6-Dichloronicotinate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 44711
- Product name
- Methyl2,6-Dichloronicotinate,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $45.27
- Updated
- 2021/12/16
Methyl 2,6-dichloronicotinate Chemical Properties,Usage,Production
Uses
Replacement of chlorides with fluorides using anhydrous nucleophilic fluoride salts generated from potassium fluoride and an arene transfer agent.
Synthesis
67-56-1
38496-18-3
65515-28-8
General procedure for the synthesis of methyl 2,6-dichloronicotinate from methanol and 2,6-dichloronicotinic acid: to a solution of 2,6-dichloronicotinic acid (5.0 g, 26 mmol) in methanol (100 mL) was slowly added thionyl chloride (0.1 mL). The reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in ethyl acetate and washed sequentially with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give methyl 2,6-dichloronicotinate (5.37 g, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.13 (d, J=8.1 Hz, 1H), 7.33 (d, J=8.1 Hz, 1H), 3.94 (s, 3H).
References
[1] Patent: US2005/119251, 2005, A1. Location in patent: Page/Page column 20; 22
[2] Patent: WO2006/14168, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2008/16643, 2008, A2. Location in patent: Page/Page column 233
[4] Patent: WO2006/88836, 2006, A2. Location in patent: Page/Page column 78
[5] Patent: WO2006/88920, 2006, A1. Location in patent: Page/Page column 133-134
Methyl 2,6-dichloronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2,6-dichloronicotinate manufacturers
- Product
- METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA 65515-28-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14