CHRYSOMYCIN B

Product Name: CHRYSOMYCIN B
CAS No.: 83852-56-6
Chemical Name: CHRYSOMYCIN B
Synonyms: B,ChrysoMycin;CHRYSOMYCIN B USP/EP/BP;ChrysoMycin M, VirenoMycin M, Albacarcin M;6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-;4-(6-Deoxy-3-C-methyl-beta-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one;6H-Benzo[d]naphtho[1,2-b]pyran-6-one,4-(6-deoxy-3-C-methyl-b-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl- (9CI)
CBNumber: CB3503294
Molecular Formula: C27H28O9
Formula Weight: 496.51
MOL File: 83852-56-6.mol

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CHRYSOMYCIN B Property

Boiling point:: 784.0±60.0 °C(Predicted)
Density: 1.410
storage temp.: 2-8°C
solubility: DMF: soluble
form: solid
pka: 8.59±0.20(Predicted)
color: Yellow to greenish

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6491
Product name: Chrysomycin B
Purity: ≥98%(HPLC),solid
Packaging: 100μg
Price: $305
Updated: 2022/05/15

Cayman Chemical

Product number: 14189
Product name: Chrysomycin B
Purity: ≥98%
Packaging: 250μg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 14189
Product name: Chrysomycin B
Purity: ≥98%
Packaging: 1mg
Price: $395
Updated: 2024/03/01

TRC

Product number: C433035
Product name: Chrysomycin B
Packaging: 500μg
Price: $185
Updated: 2021/12/16

TRC

Product number: C433035
Product name: Chrysomycin B
Packaging: 250μg
Price: $115
Updated: 2021/12/16

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CHRYSOMYCIN B Chemical Properties,Usage,Production

Description

Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.

Uses

Chrysomycin B is a minor analogue in a complex of C-glycoside antitumour actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumour active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.

Uses

Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated cross-linkers of DNA to histones.

Uses

Chrysomycin B is an inhibitor of the catalytic activity of human topoisomerase II.

storage

+4°C

CHRYSOMYCIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CHRYSOMYCIN B Suppliers

China 27 India 1 Switzerland 1 United Kingdom 2 United States 5 Global 36

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View Lastest Price from CHRYSOMYCIN B manufacturers

Dideu Industries Group Limited

Product: CHRYSOMYCIN B 83852-56-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

Career Henan Chemical Co

Product: CHRYSOMYCIN B 83852-56-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-03-11

83852-56-6, CHRYSOMYCIN BRelated Search:

Epothilone B Flavomycin Menadiol monoacetate 1-naphthyl benzoate 2,5-DIMETHYL-3-HYDROXY BENZOIC ACID CHRYSOMYCIN A CHRYSOMYCIN B 1-METHOXYNAPHTHALEN-4-YL ACETATE 2,5-DIHYDROXY-4'-METHYLBIPHENYL 2-BIPHENYL-(3'-METHOXY)CARBOXYLIC ACID

6H-Benzo[d]naphtho[1,2-b]pyran-6-one,4-(6-deoxy-3-C-methyl-b-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl- (9CI)

ChrysoMycin M, VirenoMycin M, Albacarcin M

4-(6-Deoxy-3-C-methyl-beta-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one

B,ChrysoMycin

6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-

CHRYSOMYCIN B USP/EP/BP

83852-56-6

A - KAntibiotics

Antibacterial

Antibiotics A to

Antibiotics A-FAntibiotics

Antibiotics by Application

Antineoplastic and Immunosuppressive AntibioticsAntibiotics

Inhibits an EnzymeEnzyme Inhibitors by Enzyme

Mechanism of Action

R to

Spectrum of Activity

Topoisomerase II