LEUKOTRIENE D4 METHYL ESTER
- Product Name
- LEUKOTRIENE D4 METHYL ESTER
- CAS No.
- 103476-23-9
- Chemical Name
- LEUKOTRIENE D4 METHYL ESTER
- Synonyms
- Reaxys ID: 5181548;LEUKOTRIENE D4 METHYL ESTER;Glycine, S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-hydroxy-5-methoxy-5-oxopentyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl- (9CI)
- CBNumber
- CB3503759
- Molecular Formula
- C26H42N2O6S
- Formula Weight
- 510.69
- MOL File
- 103476-23-9.mol
LEUKOTRIENE D4 METHYL ESTER Property
- storage temp.
- -20°C
- solubility
- DMF: 20 mg/ml
DMSO: 20 mg/ml
Ethanol: 1 mg/mlPBS (pH 7.2): .15 mg/ml
N-Bromosuccinimide Price
- Product number
- 10007165
- Product name
- Leukotriene D4 methyl ester
- Purity
- ≥97%
- Packaging
- 25μg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 10007165
- Product name
- Leukotriene D4 methyl ester
- Purity
- ≥97%
- Packaging
- 50μg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 10007165
- Product name
- Leukotriene D4 methyl ester
- Purity
- ≥97%
- Packaging
- 100μg
- Price
- $519
- Updated
- 2024/03/01
LEUKOTRIENE D4 METHYL ESTER Chemical Properties,Usage,Production
Description
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2 LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4 LTD4 is several hundred fold more potent than LTC4 at the cysteinyl-leukotriene 1 (CysLT1) receptor, but they exhibit approximately equal affinity at the CysLT2 receptor.5,6 LTD4 methyl ester is a more lipid soluble form of LTD4. The biological activity of LTD4 methyl ester has not been reported.WARNING This product is not for human or veterinary use.
References
[1] L ORNING B S S Hammarström. Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1980, 77 4: 2014-2017. DOI: 10.1073/pnas.77.4.2014
[2] S HAMMARSTRÖM K B L Orning. Metabolism of leukotrienes.[J]. Molecular and Cellular Biochemistry, 1985, 69 1: 7-16. DOI: 10.1007/bf00225922
[3] PER HEDQVIST. Biological profile of Ieukotrienes C4 and D4[J]. Acta Physiologica, 1980, 110 3: 331-333. DOI: 10.1111/j.1748-1716.1980.tb06676.x
[4] BENGT SAMUELSSON. Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects[J]. Science, 1987, 237 4819. DOI: 10.1126/science.2820055
[5] KEVIN R. LYNCH. Characterization of the human cysteinyl leukotriene CysLT1 receptor[J]. Nature, 1999, 399 6738: 789-793. DOI: 10.1038/21658
[6] C E HEISE. Characterization of the human cysteinyl leukotriene 2 receptor.[J]. The Journal of Biological Chemistry, 2000, 275 39: 30531-30536. DOI: 10.1074/jbc.m003490200
LEUKOTRIENE D4 METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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