NANAOMYCIN A

Product Name: NANAOMYCIN A
CAS No.: 52934-83-5
Chemical Name: NANAOMYCIN A
Synonyms: os-3966-a;Nanaomycin;rosanomycina;heptauromycin;(1s-e)-10-dioxo;OS-3966-A; ROSANOMYCINA;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
CBNumber: CB3503991
Molecular Formula: C16H14O6
Formula Weight: 302.28
MOL File: 52934-83-5.mol

More

Less

NANAOMYCIN A Property

Melting point:: 179°C
Boiling point:: 363.32°C (rough estimate)
Density: 1.2514 (rough estimate)
refractive index: 1.4600 (estimate)
storage temp.: −20°C
solubility: insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic
form: solid
color: Yellow to orange

More

Less

Safety

Hazard Codes: T
Risk Statements: 22-24
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: QL6127000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 10mM(in 1mL DMSO)
Price: $340
Updated: 2021/12/16

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 5mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010483
Product name: 1H-NAPHTHO[2,3-C]PYRAN-3-ACETIC ACID, 3,4,5,10-TETRAHYDRO-9-HYDROXY-1-METHYL-5,10-DIOXO-(1S,3R)-
Purity: 95.00%
Packaging: 5MG
Price: $500.38
Updated: 2021/12/16

ApexBio Technology

Product number: A8191
Product name: NanaomycinA
Packaging: 25mg
Price: $1000
Updated: 2021/12/16

ChemScene

Product number: CS-0027820
Product name: NanaomycinA
Purity: ≥98.0%
Packaging: 5mg
Price: $1050
Updated: 2021/12/16

More

Less

NANAOMYCIN A Chemical Properties,Usage,Production

Definition

ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.

Biological Activity

nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1].

target

DNMT3B

References

[1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023.

NANAOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NANAOMYCIN A Suppliers

China 20 South Korea 1 Switzerland 1 United States 6 Global 28

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai Puluokai Medical Technology Co., LTD

Tel: 17269768198
Fax: QQ:1213744847
Email: prochemx@163.com
Country: China
ProdList: 613
Advantage: 58

52934-83-5, NANAOMYCIN ARelated Search:

Gentamicin sulfate

(1s-e)-10-dioxo

1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,

os-3966-a

rosanomycina

Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-

(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid

(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid

OS-3966-A; ROSANOMYCINA

Nanaomycin

heptauromycin

52934-83-5