NANAOMYCIN A
- Product Name
- NANAOMYCIN A
- CAS No.
- 52934-83-5
- Chemical Name
- NANAOMYCIN A
- Synonyms
- os-3966-a;Nanaomycin;rosanomycina;heptauromycin;(1s-e)-10-dioxo;OS-3966-A; ROSANOMYCINA;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
- CBNumber
- CB3503991
- Molecular Formula
- C16H14O6
- Formula Weight
- 302.28
- MOL File
- 52934-83-5.mol
NANAOMYCIN A Property
- Melting point:
- 179°C
- Boiling point:
- 363.32°C (rough estimate)
- Density
- 1.2514 (rough estimate)
- refractive index
- 1.4600 (estimate)
- storage temp.
- −20°C
- solubility
- insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic
- form
- solid
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H310Fatal in contact with skin
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A8191
- Product name
- NanaomycinA
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $340
- Updated
- 2021/12/16
- Product number
- A8191
- Product name
- NanaomycinA
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- API0010483
- Product name
- 1H-NAPHTHO[2,3-C]PYRAN-3-ACETIC ACID, 3,4,5,10-TETRAHYDRO-9-HYDROXY-1-METHYL-5,10-DIOXO-(1S,3R)-
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.38
- Updated
- 2021/12/16
- Product number
- A8191
- Product name
- NanaomycinA
- Packaging
- 25mg
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- CS-0027820
- Product name
- NanaomycinA
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $1050
- Updated
- 2021/12/16
NANAOMYCIN A Chemical Properties,Usage,Production
Definition
ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.
Biological Activity
nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1].
target
DNMT3B
References
[1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023.
NANAOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
NANAOMYCIN A Suppliers
- Tel
- --
- Fax
- --
- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
- Advantage
- 74