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NANAOMYCIN A

Product Name
NANAOMYCIN A
CAS No.
52934-83-5
Chemical Name
NANAOMYCIN A
Synonyms
os-3966-a;Nanaomycin;rosanomycina;heptauromycin;(1s-e)-10-dioxo;OS-3966-A; ROSANOMYCINA;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
CBNumber
CB3503991
Molecular Formula
C16H14O6
Formula Weight
302.28
MOL File
52934-83-5.mol
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NANAOMYCIN A Property

Melting point:
179°C
Boiling point:
363.32°C (rough estimate)
Density 
1.2514 (rough estimate)
refractive index 
1.4600 (estimate)
storage temp. 
−20°C
solubility 
insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic
form 
solid
color 
Yellow to orange
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Safety

Hazard Codes 
T
Risk Statements 
22-24
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
QL6127000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A8191
Product name
NanaomycinA
Packaging
10mM(in 1mL DMSO)
Price
$340
Updated
2021/12/16
ApexBio Technology
Product number
A8191
Product name
NanaomycinA
Packaging
5mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010483
Product name
1H-NAPHTHO[2,3-C]PYRAN-3-ACETIC ACID, 3,4,5,10-TETRAHYDRO-9-HYDROXY-1-METHYL-5,10-DIOXO-(1S,3R)-
Purity
95.00%
Packaging
5MG
Price
$500.38
Updated
2021/12/16
ApexBio Technology
Product number
A8191
Product name
NanaomycinA
Packaging
25mg
Price
$1000
Updated
2021/12/16
ChemScene
Product number
CS-0027820
Product name
NanaomycinA
Purity
≥98.0%
Packaging
5mg
Price
$1050
Updated
2021/12/16
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NANAOMYCIN A Chemical Properties,Usage,Production

Definition

ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.

Biological Activity

nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1].

target

DNMT3B

References

[1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023.

NANAOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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NANAOMYCIN A Suppliers

China 20 South Korea 1 Switzerland 1 United States 6 Global 28
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

52934-83-5, NANAOMYCIN ARelated Search:

Gentamicin sulfate

  • (1s-e)-10-dioxo
  • 1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,
  • os-3966-a
  • rosanomycina
  • Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
  • (1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid
  • (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid
  • OS-3966-A; ROSANOMYCINA
  • Nanaomycin
  • heptauromycin
  • 52934-83-5