ChemicalBook > CAS DataBase List > OXIDIZED NIFEDIPINE

OXIDIZED NIFEDIPINE

Product Name
OXIDIZED NIFEDIPINE
CAS No.
67035-22-7
Chemical Name
OXIDIZED NIFEDIPINE
Synonyms
B 4759;BAY-b-4759;Nifedipine-1;Dehydro Nifedipine;NIFEDIPINE EP IMP A;Nifidipine Impurity A;Nitrophenyl nifedipine;Nifedipine impurity A CRS;Nifedipine impurity A (EP);Divalproex Sodium Impurity 1
CBNumber
CB3505238
Molecular Formula
C17H16N2O6
Formula Weight
344.32
MOL File
67035-22-7.mol
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OXIDIZED NIFEDIPINE Property

Melting point:
100-105 °C
Boiling point:
443.7±45.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder
pka
1.55±0.29(Predicted)
color 
yellow
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
UC167
Product name
Oxidized Nifedipine
Purity
powder, ~95% (HPLC)
Packaging
5mg
Price
$469
Updated
2024/03/01
Sigma-Aldrich
Product number
1463600
Product name
Nifedipine Nitrophenylpyridine Analog
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1530
Updated
2024/03/01
Cayman Chemical
Product number
23229
Product name
Dehydro Nifedipine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23229
Product name
Dehydro Nifedipine
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
UC167
Product name
Oxidized Nifedipine
Purity
powder, ~95% (HPLC)
Packaging
10mg
Price
$861
Updated
2024/03/01
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OXIDIZED NIFEDIPINE Chemical Properties,Usage,Production

Description

Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.

Chemical Properties

Pale Yellow Solid

Uses

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Uses

The main Nifedipine metabolite in human plasma

Definition

ChEBI: Dehydronifedipine is a phenylpyridine.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

OXIDIZED NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OXIDIZED NIFEDIPINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Oxidized Nifedipine 67035-22-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2019-12-27

67035-22-7, OXIDIZED NIFEDIPINERelated Search:

Nifedipine METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE Methyl 3-aminocrotonate 2,6-Ntp Dehydro Nifedipine N-Oxide diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nifedipine Impurity J Hydroxydehydro Nifedipine Carboxylate methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate Nifedipine Impurity 9 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER Nifendipine Impurity G nifedipine iMpurity C Hydroxy Dehydro Nifedipine Lactone 3-aminocrotonamide Nifedipine impurity 10 Nifedipine EP IMpurity-B Nifedipine EP IMpurity-C

  • Nifedipine-1
  • Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined
  • Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • 2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine
  • Divalproex Sodium Impurity 1
  • Nifedipine Nitrophenylpyridine Analog
  • dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate
  • Nifedipine impurity A (EP)
  • Dimethyl 4-(2-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
  • dimethyl2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
  • 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • B 4759
  • Dehydro Nifedipine
  • 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(2-Nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester
  • BAY-b-4759
  • Nitrophenyl nifedipine
  • Nifedipine Impurity Ⅰ（Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)pyridine-3,5-Dicarboxylate）
  • Nifedipine impurity A CRS
  • Dimethyl 2,6-Dimethyl-4-(2-nitrophe
  • Nifedipine EP Impurity A/Dehydro Nifedipine
  • 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester
  • Nifidipine Impurity A
  • Nifedipine EP Impurity A (Nifedipine nitrophenylpyridine analogue)
  • Azilsartan medoxomil impurity308
  • DehydronifedipineQ: What is Dehydronifedipine Q: What is the CAS Number of Dehydronifedipine Q: What is the storage condition of Dehydronifedipine Q: What are the applications of Dehydronifedipine
  • Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • Nifedipine nitrophenylpyridine Analogue
  • dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (nitrophenylpyridine analogue)
  • _x000b_Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined
  • Nifedipine EP impurity A Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5- dicarboxylate (nitrophenylpyridine analogue)
  • NIFEDIPINE EP IMP A
  • 67035-22-7
  • 34432
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals