ChemicalBook > CAS DataBase List > 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID
4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID
Uses- Product Name
- 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS No.
- 320-37-6
- Chemical Name
- 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID
- Synonyms
- 4-Nitro-2-trifluoromethylbenzo;2-Carboxy-5-nitrobenzotrifluoride;2-TrifluoroMethyl-4-nitrobenzoic acid;4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID;Benzoic acid, 4-nitro-2-(trifluoromethyl)-;4-Nitro-2-(trifluoromethyl)benzoic acid 97%;4-Nitro-2-(trifluoromethyl)benzoic acid,97%
- CBNumber
- CB3505324
- Molecular Formula
- C8H4F3NO4
- Formula Weight
- 235.12
- MOL File
- 320-37-6.mol
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4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID Property
- Melting point:
- 138-142 °C (lit.)
- Boiling point:
- 321.4±42.0 °C(Predicted)
- Density
- 1.596±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.40±0.32(Predicted)
- form
- Powder
- color
- White to off-white
- InChIKey
- BPCKZQCTLCTDST-UHFFFAOYSA-N
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 638706
- Product name
- 4-Nitro-2-(trifluoromethyl)benzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $75.3
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 638706
- Product name
- 4-Nitro-2-(trifluoromethyl)benzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $196
- Updated
- 2022/05/15
TCI Chemical
- Product number
- N1037
- Product name
- 4-Nitro-2-(trifluoromethyl)benzoic Acid
- Packaging
- 1G
- Price
- $31
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N1037
- Product name
- 4-Nitro-2-(trifluoromethyl)benzoic Acid
- Packaging
- 5G
- Price
- $93
- Updated
- 2025/07/31
TRC
- Product number
- N596980
- Product name
- 4-Nitro-2-(trifluoromethyl)benzoic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
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4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID Chemical Properties,Usage,Production
Uses
4-Nitro-2-(trifluoromethyl)benzoic acid is a carboxylic acid derivative, mainly used as a pharmaceutical and pesticide intermediate.
Chemical Properties
white to light yellow crystal powder
Synthesis
433-97-6
320-37-6
A mixture of 2-trifluoromethylbenzoic acid (1 eq.) and concentrated sulfuric acid (22 eq.) was placed in a mechanical stirrer under nitrogen protection and cooled to 0-5 °C in an ice bath. Subsequently, fuming nitric acid (9.8 eq.) was slowly added dropwise at the same temperature for 60 minutes. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was allowed to continue stirring at room temperature for 120 minutes. Upon completion of the reaction, the mixture was slowly poured into ice water and stirred at room temperature for 60 minutes. The suspension was collected by filtration and washed with cold water to give the crude 4-nitro-2-trifluoromethylbenzoic acid. To remove the regional isomers, the crude product was recrystallized from water to give the final pure product in 45% yield. The melting point range was 137-142°C.
References
[1] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 17; 18
[2] J. Gen. Chem. USSR (Engl. Transl.), 1963, vol. 33, p. 2957 - 2960
[3] Zhurnal Obshchei Khimii, 1963, vol. 33, # 9, p. 3031 - 3035
[4] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 61
[5] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 61
4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID 320-37-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-12
Honest Joy Holdings Limited
- Product
- 4-nitro-2-(trifluoromethyl)benzoic acid 320-37-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
Career Henan Chemical Co
- Product
- 4-Nitro-2-(trifluoromethyl)benzoic acid 320-37-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25
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