ChemicalBook > CAS DataBase List > 2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID

2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID

Product Name
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
CAS No.
303175-44-2
Chemical Name
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
Synonyms
ATR-002;PD0184264;zapnometinib;Zapnometinib (PD0184264);2-(2-chloro-4-iodoanilino)-3;2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid;4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid;2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID;3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid;Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-
CBNumber
CB3507580
Molecular Formula
C13H7ClF2INO2
Formula Weight
409.5544564
MOL File
Mol file
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2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Property

Melting point:
230-231 °C
Boiling point:
401.5±45.0 °C(Predicted)
Density 
1.946±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.25±0.36(Predicted)
color 
White to Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3472
Product name
ATR-002
Purity
≥98% (HPLC)
Packaging
5MG
Price
$63.46
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3472
Product name
ATR-002
Purity
≥98% (HPLC)
Packaging
25MG
Price
$268
Updated
2025/07/31
TRC
Product number
C367210
Product name
2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoicAcid
Packaging
100mg
Price
$395
Updated
2021/12/16
TRC
Product number
C367210
Product name
2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoicAcid
Packaging
50mg
Price
$205
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20093
Product name
2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic acid
Packaging
25mg
Price
$250
Updated
2021/12/16
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2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Light-Brown Solid

Uses

2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic Acid (cas# 303175-44-2) is a compound useful in organic synthesis.

Biological Activity

ATR-002, a derivate of CI-1040, is a cell penetrant, potent and specific inhibitor of the Raf/MEK/ERK pathway. ATR-002 exhibits strong anti-influenza and anti-SARS-CoV-2 activity. It impairs the influenzas and SARS-CoV-2 viruses induced expression of pro-inflammatory cytokines.

in vivo

Zapnometinib (8.4-75 mg/kg/day; three times a day p.o.) reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
Zapnometinib (150 mg/kg) exhibits AUC values of 860.02 and 1953.68 μg h/mL in mice by i.v. or oral route, respectively[1].

Animal Model:Female C57BL/6 mice (8 weeks; 21-24 g) were infected with H1N1pdm09[1]
Dosage:8.4, 25, 75 mg/kg/day (2.8, 8.4, 25 mg/kg)
Administration:P.o. three times a day
Result:Significantly reduced the virus titer at the dose of either 75 mg/kg/day or 25 mg/kg/day.

IC 50

MEK: 5.7 nM (IC50)

2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID Suppliers

Canada 1 China 41 India 1 United Kingdom 1 United States 5 Global 49
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View Lastest Price from 2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID 303175-44-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

303175-44-2, 2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACIDRelated Search:

3,4-Difluorobenzoic acid

  • 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid
  • 2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
  • Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-
  • ATR-002
  • PD0184264
  • 2-(2-chloro-4-iodoanilino)-3
  • 4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid
  • zapnometinib
  • 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid
  • Zapnometinib (PD0184264)
  • antiviral,virus,MAPKK,zapnometinib,Influenza Virus,ATR002,Bacterial,CI-1040,Inhibitor,PD 0184264,Mitogen-activated protein kinase kinase,PD-0184264,antibacterial,inhibit,ATR 002,influenza,MAP2K,MEK
  • 303175-44-2
  • C13H7ClF2INO2
  • Amines
  • Aromatics
  • Chemical Amines