3,4-Difluorobenzoic acid
- Product Name
- 3,4-Difluorobenzoic acid
- CAS No.
- 455-86-7
- Chemical Name
- 3,4-Difluorobenzoic acid
- Synonyms
- NSC 190686;3,4-Difluorobenzoic;TIMTEC-BB SBB006721;RARECHEM AL BO 0269;3,4-Difluorbenzoicacid;3,4-Difuorobenzoic acid;3,4-DIFLUOROBENZOIC ACID;3, 4-2 fluoro benzoic acid;3,4-DifluorobenzoicAcid>3,4-Difluorobenzoicacid,98%
- CBNumber
- CB7152724
- Molecular Formula
- C7H4F2O2
- Formula Weight
- 158.1
- MOL File
- 455-86-7.mol
3,4-Difluorobenzoic acid Property
- Melting point:
- 120-122 °C(lit.)
- Boiling point:
- 257.0±20.0 °C(Predicted)
- Density
- 1.3486 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 3.80±0.10(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- slightly soluble in cold water
- BRN
- 2085848
- InChI
- InChI=1S/C7H4F2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)
- InChIKey
- FPENCTDAQQQKNY-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C(F)=C1
- CAS DataBase Reference
- 455-86-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,4-Difluorobenzoic acid(455-86-7)
- EPA Substance Registry System
- Benzoic acid, 3,4-difluoro- (455-86-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 264318
- Product name
- 3,4-Difluorobenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $37.6
- Updated
- 2025/07/31
- Product number
- D1908
- Product name
- 3,4-Difluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- D1908
- Product name
- 3,4-Difluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $232
- Updated
- 2025/07/31
- Product number
- D445480
- Product name
- 3,4-Difluorobenzoic acid
- Packaging
- 25g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- D445480
- Product name
- 3,4-Difluorobenzoic acid
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
3,4-Difluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3,4-Difluoro-benzoic Acid is a useful synthetic intermediate. It is used to synthesize 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
General Description
Ultra-trace determination of 3,4-difluorobenzoic acid in aqueous reservoir fluids has been reported using solid-phase extraction in combination with GC-MS.
Synthesis
2927-34-6
455-86-7
Example 5: Synthesis of 3,4-difluorobenzoic acid. In a 100 mL jacketed reactor, 200 mL of acetic acid, 0.05 g of manganese(II) acetate, 1.91 g of sulfuric acid, and 14.1 g of 3,4-difluorotoluene were added sequentially. The reaction mixture was cooled to 16°C, followed by the slow passage of 4.0 g of ozone over 60 min. Upon completion of the ozonolysis reaction, the reaction system was purged with nitrogen to remove residual ozone. HPLC or GC analysis of the reaction mixture showed that the residue of 3,4-difluorotoluene was <0.1%; the yield of 3,4-difluorobenzoic acid was 98%.
References
[1] Patent: US2003/216577, 2003, A1. Location in patent: Page/Page column 4
3,4-Difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Difluorobenzoic acid manufacturers
- Product
- 3,4-Difluorobenzoic acid 455-86-7
- Price
- US $65.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300MT/year
- Release date
- 2019-10-17
- Product
- 3,4-Difluorobenzoic acid 455-86-7
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 3,4-Difluorobenzoic acid 455-86-7
- Price
- US $100.00-65.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-22