Pharmacology Tolerability
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Docetaxel trihydrate

Pharmacology Tolerability
Product Name
Docetaxel trihydrate
CAS No.
148408-66-6
Chemical Name
Docetaxel trihydrate
Synonyms
Xrp6976;Taxespira;Unii-15H5577cqd;DOCETAXEL HYDRATE;Docetaxel (200 mg);Taxotere Trihydrate;Docetaxel (1224551);Docetaxel trihydrate;Docetaxel Tryhydrate;Docetaxel(trihydrous)
CBNumber
CB3511420
Molecular Formula
C43H55NO15
Formula Weight
825.91
MOL File
148408-66-6.mol
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Docetaxel trihydrate Property

Melting point:
186-192°C
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
form 
Solid
color 
White to OFf-White
Stability:
Hygroscopic
InChIKey
XCDIRYDKECHIPE-KHDBCEGQSA-N
CAS DataBase Reference
148408-66-6(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2932996560
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1883
Product name
Docetaxel trihydrate
Packaging
200mg
Price
$342
Updated
2024/03/01
Sigma-Aldrich
Product number
1224551
Product name
Docetaxel for system suitability
Packaging
200mg
Price
$3550
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001155
Product name
Docetaxel for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001155
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001133
Product name
Docetaxel trihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001133
Price
$220
Updated
2024/03/01
Usbiological
Product number
447603
Product name
Docetaxel Trihydrate
Packaging
5mg
Price
$496
Updated
2021/12/16
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Docetaxel trihydrate Chemical Properties,Usage,Production

Pharmacology

Docetaxel principally exerts its cytotoxic activity by promoting and stabilising microtubule assembly while simultaneously preventing microtubule depolymerisation. This results in inhibition of normal cell division. In vitro and in vivo, docetaxel has antineoplastic activity against a wide range of cancer cells, demonstrates synergistic activity with several antineoplastic agents and often has greater cytotoxic activity against human breast cancer cell lines than paclitaxel. Docetaxel, binds to and stabilizes tubulin, which prevents physiological microtubule depolymerization/disassembly and results in cell-cycle arrest at the G2/M phase and cell death. This agent also is known to inhibit the anti-apoptotic gene Bcl2 and to encourage the expression of p27, a cell-cycle inhibitor, and further pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes, and its clearance has been shown to be related to body surface area and hepatic enzyme and alpha1 acid glycoprotein plasma levels.

Tolerability

The tolerability of docetaxel in comparative clinical trials was generally acceptable. Severe neutropenia affects most docetaxel recipients, with febrile neutropenia occurring in approximately one-eighth of patients. Dose-cumulative severe fluid retention was reported in docetaxel recipients, despite premedication with prophylactic corticosteroids. Other adverse events include asthenia, stomatitis, infections, neurosensory, cutaneous or gastrointestinal events, nail changes, severe fever in the absence of infection, myalgia and hypersensitivity reactions.

Chemical Properties

White Crystalline Powder

Uses

An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin

Uses

Docetaxel Trihydrate is an anti-cancer drugs; Semisynthetic analog of the taxane paclitaxel.

Definition

ChEBI: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.

brand name

Taxotere (Sanofi Aventis).

Docetaxel trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Docetaxel trihydrate Suppliers

VIVAN Life Sciences Pvt. Limited.
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India
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Pharma Affiliates
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Pharmaffiliates Analytics and Synthetics P. Ltd
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India
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SynZeal Research Pvt Ltd
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standards@synzeal.com
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India
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A.J Chemicals
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sales@ajchem.in
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India
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MSN LABORATORIES PRIVATE LIMITED
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India
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FRESENIUS KABI ONCOLOGY LIMITED
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MSN LABORATORIES PRIVATE LTD
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MAC CHEM PRODUCTS INDIA PVT LTD
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EMCURE PHARMACEUTICALS LTD
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commercial@zuventus.com
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View Lastest Price from Docetaxel trihydrate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Docetaxel Trihydrate 148408-66-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-12-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
Docetaxel (Trihydrate) 148408-66-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Docetaxel (Trihydrate) 148408-66-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

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