ChemicalBook > CAS DataBase List > PFE-360
PFE-360
- Product Name
- PFE-360
- CAS No.
- 1527475-61-1
- Chemical Name
- PFE-360
- Synonyms
- PFE-360;PF-06685360;1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile;1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-;1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile , PFE-360;PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
- CBNumber
- CB35419811
- Molecular Formula
- C16H16N6O
- Formula Weight
- 308.34
- MOL File
- 1527475-61-1.mol
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PFE-360 Property
- storage temp.
- room temp
- solubility
- DMSO: 2 mg/mL, clear
- form
- powder
- color
- white to beige
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PFE-360 Chemical Properties,Usage,Production
Description
PFE-360 (PF-06685360) is a poten and elective inhibitor of LRRK2 kinase.
in vitro
PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment potently decreases the LRRK2-pSer935/total LRRK2 ratio, with no significant adverse effects.
animal Model: Female Sprague Dawley rats (NTac:SD) weighed 225-250 g.
Dosage: 4 mg/kg and 7.5 mg/kg (pharmacokinetics and pharmacodynamics).
Administration: Orally BID for 10-12 weeks.
Result: The LRRK2-pSer935/total LRRK2 ratio was significantly decreased at both 1 h and 12 h after dosing.
The terminal bodyweights exhibited no significant changes.
PFE-360 Preparation Products And Raw materials
Raw materials
Preparation Products
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PFE-360 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58