KL-1333

Product Name: KL-1333
CAS No.: 1800405-30-4
Chemical Name: KL-1333
Synonyms: KL-1333;Napazimone;NQO1 ACTIVATOR 1;KL1333, 10 mM in DMSO;Napazimone intermediate;KL-1333(NQO1 activator 1);2-Isopropyl-3H-naphtho[1,2-d]imidazole-4,5-dione;2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione;3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)-;2-(propan-2-yl)-1H,4H,5H-naphtho[1,2-d]imidazole-4,5-dione
CBNumber: CB35424910
Molecular Formula: C14H12N2O2
Formula Weight: 240.26
MOL File: 1800405-30-4.mol

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KL-1333 Property

Boiling point:: 517.3±19.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (1040.54 mM)
pka: 8.58±0.20(Predicted)
form: Solid
color: Reddish brown to red
InChI: InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16)
InChIKey: AJFWITSBVLLDCC-UHFFFAOYSA-N
SMILES: C1(C(C)C)NC2C(=O)C(=O)C3=C(C=2N=1)C=CC=C3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0102150
Product name: KL1333
Purity: >98.0%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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KL-1333 Chemical Properties,Usage,Production

Uses

KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2].

References

[1] Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018;9:552. Published 2018 Jul 5. DOI:10.3389/fneur.2018.00552
[2] Lee HS, et al. KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020;126:110068. DOI:10.1016/j.biopha.2020.110068

KL-1333 Preparation Products And Raw materials

Raw materials

Preparation Products

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KL-1333 Suppliers

China 52 United States 4 Global 56

Shanghai Mumin Biotechnology Co., Ltd

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TargetMol Chemicals Inc.

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1800405-30-4, KL-1333Related Search:

NQO1 ACTIVATOR 1

KL-1333

3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)-

2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione

KL-1333(NQO1 activator 1)

Mitochondrial Metabolism,KL 1333,KL1333,Inhibitor,inhibit,KL-1333

2-Isopropyl-3H-naphtho[1,2-d]imidazole-4,5-dione

2-(propan-2-yl)-1H,4H,5H-naphtho[1,2-d]imidazole-4,5-dione

KL1333, 10 mM in DMSO

Napazimone

Napazimone intermediate

1800405-30-4