ChemicalBook > CAS DataBase List > CDK8-IN-1
CDK8-IN-1
- Product Name
- CDK8-IN-1
- CAS No.
- 1629633-48-2
- Chemical Name
- CDK8-IN-1
- Synonyms
- CDK8-IN-1;CDK8-IN-16;CDK8-IN-1, 10 mM in DMSO;CDK8IN1,CDK-8-IN-1,CDK8 IN 1;1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)-
- CBNumber
- CB35540351
- Molecular Formula
- C11H8F3N3O
- Formula Weight
- 255.2
- MOL File
- 1629633-48-2.mol
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CDK8-IN-1 Property
- Boiling point:
- 406.2±45.0 °C(Predicted)
- Density
- 1.429±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 12.46±0.50(Predicted)
- color
- White to light brown
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CDK8-IN-1 Chemical Properties,Usage,Production
Description
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].
References
[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.
CDK8-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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CDK8-IN-1 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58