SPR-741

Product Name: SPR-741
CAS No.: 1179330-52-9
Chemical Name: SPR-741
Synonyms: NAB741;SPR-741;SPR741TFA;SPR741 (NAB741);2-10-Polymyxin B1, N-acetyl-3-D-serine-
CBNumber: CB35590033
Molecular Formula: C44H73N13O13
Formula Weight: 992.15
MOL File: 1179330-52-9.mol

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SPR-741 Property

Boiling point:: 1515.0±65.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
pka: 12.78±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC27000
Product name: SPR741(NAB741)
Packaging: 50mg
Price: $900
Updated: 2021/12/16

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SPR-741 Chemical Properties,Usage,Production

Uses

SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].

in vivo

SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741^[1].

References

[1] Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00200-17. DOI:10.1128/AAC.00200-17
[2] Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00892-19. DOI:10.1128/AAC.00892-19

SPR-741 Preparation Products And Raw materials

Raw materials

Preparation Products

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SPR-741 Suppliers

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1179330-52-9, SPR-741Related Search:

SPR-741

NAB741

2-10-Polymyxin B1, N-acetyl-3-D-serine-

SPR741 (NAB741)

SPR741TFA

1179330-52-9

C44H73N13O13