SPR-741
- Product Name
- SPR-741
- CAS No.
- 1179330-52-9
- Chemical Name
- SPR-741
- Synonyms
- NAB741;SPR-741;SPR741TFA;SPR741 (NAB741);2-10-Polymyxin B1, N-acetyl-3-D-serine-
- CBNumber
- CB35590033
- Molecular Formula
- C44H73N13O13
- Formula Weight
- 992.15
- MOL File
- 1179330-52-9.mol
SPR-741 Property
- Boiling point:
- 1515.0±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- pka
- 12.78±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- DC27000
- Product name
- SPR741(NAB741)
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
SPR-741 Chemical Properties,Usage,Production
Uses
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].
in vivo
SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741[1].
References
[1] Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00200-17. DOI:10.1128/AAC.00200-17
[2] Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00892-19. DOI:10.1128/AAC.00892-19
SPR-741 Preparation Products And Raw materials
Raw materials
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