GAB1 antibody
Source Reactivity Background References- Product Name
- GAB1 antibody
- Chemical Name
- GAB1 antibody
- Synonyms
- GAB1 antibody;Mouse Monoclonal GAB1 Antibody
- CBNumber
- CB35629074
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb6061
- Product name
- Gab1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb6061
- Product name
- Gab1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
GAB1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The Grb-associated binder family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their cognate ligand, Gab is recruited to the plasma membrane where it is phosphorylated and functions as a scaffold. Multiple tyrosine phosphorylation sites of Gab1 protein have been identified. Phosphorylation of Tyr472 regulates its binding to p85 PI3 kinase. Phosphorylation of Gab1 at Tyr307, Tyr373 and Tyr407 modulates its association to PLCγ. Phosphorylation of Tyr627 and Tyr659 is required for Gab1 binding to and activation of the protein tyrosine phosphatase SHP2.
References
[1] Holgado-Madruga, M. et al. (1996) Nature 379, 560-564.
[2] Weidner, K.M. et al. (1996) Nature 384, 173-176.
[3] Takahashi-Tezuka, M. et al. (1998) Mol. Cell. Biol. 18, 4109-4117.
[4] Ingham, R.J. et al. (2001) J Biol Chem 276, 12257-65.
[5] Lehr, S. et al. (1999) Biochemistry 38, 151-159.
[6] Rocchi, S. et al. (1998) Mol. Endocrinol. 12, 914-923.
[7] Yu, C.F. et al. (2001) J Biol Chem 276, 32552-8.
[8] Gual, P. et al. (2000) Oncogene 19, 1509-18.
[9] Cunnick, J.M. et al. (2001) J Biol Chem 276, 24380-7.
GAB1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
GAB1 antibody Suppliers
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