MGMT antibody
Source Reactivity Background References- Product Name
- MGMT antibody
- Chemical Name
- MGMT antibody
- Synonyms
- MGMT antibody
- CBNumber
- CB35654205
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb379005
- Product name
- MGMT antibody
- Purity
- Tissue culture supernatant
- Packaging
- 100μL
- Price
- $399.5
- Updated
- 2021/12/16
- Product number
- orb379006
- Product name
- MGMT antibody
- Purity
- Peptide affinity purified
- Packaging
- 100μL
- Price
- $399.5
- Updated
- 2021/12/16
- Product number
- orb11041
- Product name
- MGMT antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb500276
- Product name
- MGMT antibody
- Purity
- Affinity purified by Protein G
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb11041
- Product name
- MGMT antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
MGMT antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Monkey
Background
MGMT is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O(6) position of guanine, restoring guanine to its normal form without causing DNA breaks. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It is ubiquitously expressed in normal human tissues and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy.
References
[1] Pegg, A.E. (2000) Mutat. Res. 462, 83-100.
[2] Bobola, M.S. et al. (2005) Clin. Cancer Res. 11, 2747-2755.
[3] Pollack, I.F. et al. (2006) J. Clin. Oncol. 24, 3431-3437.
[4] Gerson, S.L. et al. (1986) Carcinogenesis 7, 745-749.
[5] Soejima, H. et al. (2005) Biochem. Cell Biol. 83, 429-437.
MGMT antibody Preparation Products And Raw materials
Raw materials
Preparation Products
MGMT antibody Suppliers
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