Applications Immunogen Background

PPM1A antibody

Applications Immunogen Background
Product Name
PPM1A antibody
Chemical Name
PPM1A antibody
Synonyms
PPM1A antibody;Mouse Monoclonal PPM1A Antibody
CBNumber
CB35675622
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb6774
Product name
PPM1A antibody
Purity
Affinity purified by Protein A
Packaging
100μg
Price
$421.6
Updated
2021/12/16
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PPM1A antibody Chemical Properties,Usage,Production

Applications

PPM1A antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:250 ~ 500. Recommended starting dilution is 1:250.

Immunogen

Anti-human PPM1A mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPM1A amino acids 1-382 purified from E. coli.

Background

Protein Phosphatase 2C alpha is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described. Protein phosphatase 2C(PP2Cα) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes.

PPM1A antibody Preparation Products And Raw materials

Raw materials

Preparation Products

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PPM1A antibody Suppliers

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