SMAD5 antibody
Source Reactivity Background References- Product Name
- SMAD5 antibody
- Chemical Name
- SMAD5 antibody
- Synonyms
- SMAD5 antibody;Mouse Monoclonal SMAD5 Antibody
- CBNumber
- CB35696706
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb163315
- Product name
- Smad5 antibody
- Purity
- Affinity-purified by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $280.5
- Updated
- 2021/12/16
- Product number
- orb69361
- Product name
- SMAD5 antibody
- Purity
- Ascitic fluid
- Packaging
- 100μL
- Price
- $370.6
- Updated
- 2021/12/16
- Product number
- orb100675
- Product name
- SMAD5 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $402.9
- Updated
- 2021/12/16
- Product number
- orb313124
- Product name
- SMAD5 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb166453
- Product name
- SMAD5 antibody
- Purity
- Peptide Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
SMAD5 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Rat;Monkey
Background
Bone morphogenetic proteins constitute a large family of signaling molecules that regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis. BMP receptors are members of the TGF-β superfamily of Ser/Thr kinase receptors. Ligand binding induces multimerization, autophosphorylation, and activation of these receptors. They subsequently phosphorylate SMAD1 at Ser463 and Ser465 in the carboxy-terminal motif SSXS, as well as SMAD5 and SMAD9 at their corresponding sites. These phosphorylated SMADs dimerize with the coactivating SMAD4 and translocate to the nucleus, where they regulate the transcription of target genes. MAP kinases and CDKs 8 and 9 are also reported to phosphorylate residues in the linker region of SMAD1, including Ser206. Phosphorylation of SMAD1 at Ser206 recruits Smurf1 to the linker region and leads to the degradation of SMAD1. Phosphorylation at this site also promotes SMAD1 transcriptional activity by recruiting YAP to the linker region.
References
[1] Hogan, B.L. (1996) Genes Dev 10, 1580-94.
[2] Hoodless, P.A. et al. (1996) Cell 85, 489-500.
[3] Klemm, J.D. et al. (1998) Annu Rev Immunol 16, 569-92.
[4] Kretzschmar, M. et al. (1997) Genes Dev 11, 984-95.
[5] Whitman, M. (1998) Genes Dev 12, 2445-62.
[6] Sapkota, G. et al. (2007) Mol Cell 25, 441-54.
[7] Alarcón, C. et al. (2009) Cell 139, 757-69.
SMAD5 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
SMAD5 antibody Suppliers
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- 18007124176
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